Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance
Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin...
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| Veröffentlicht in: | PloS one 2012-05, Vol.7 (5), p.e37160 |
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| creator | Moreno-Navarrete, José María Sabater, Mònica Ortega, Francisco Ricart, Wifredo Fernández-Real, José Manuel |
| description | Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase. |
| doi_str_mv | 10.1371/journal.pone.0037160 |
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To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. 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To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Biology</subject><subject>Blood Glucose - metabolism</subject><subject>Body Composition</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cholera Toxin - blood</subject><subject>Cholesterol</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Fasting</subject><subject>Glucose</subject><subject>Glucose Tolerance Test</subject><subject>High density lipoprotein</subject><subject>Hip</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Intestine</subject><subject>Intestines - 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To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22629362</pmid><doi>10.1371/journal.pone.0037160</doi><tpages>e37160</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Analysis Biology Blood Glucose - metabolism Body Composition Body mass Body mass index Body size Cholera Toxin - blood Cholesterol Enzyme-linked immunosorbent assay Fasting Glucose Glucose Tolerance Test High density lipoprotein Hip Humans Inflammation Insulin Insulin resistance Insulin Resistance - physiology Interleukin 6 Interleukin-6 - blood Intestine Intestines - metabolism Laboratory testing Lipoproteins (high density) Male Medicine Middle Aged Multiple regression analysis Obesity Obesity - blood Parameter sensitivity Permeability Physiological aspects Regression analysis Rodents Sensitivity Sensitivity analysis Small intestine Tight junctions Triglycerides Type 2 diabetes Uric acid Uric Acid - blood Waist-Hip Ratio |
| title | Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance |
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