Salivary gland-specific P. berghei reporter lines enable rapid evaluation of tissue-specific sporozoite loads in mosquitoes

Malaria is a life-threatening human infectious disease transmitted by mosquitoes. Levels of the salivary gland sporozoites (sgs), the only mosquito stage infectious to a mammalian host, represent an important cumulative index of Plasmodium development within a mosquito. However, current techniques o...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36376-e36376
Hauptverfasser:	Ramakrishnan, Chandra, Rademacher, Annika, Soichot, Julien, Costa, Giulia, Waters, Andrew P, Janse, Chris J, Ramesar, Jai, Franke-Fayard, Blandine M, Levashina, Elena A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Anopheles Anopheles gambiae Aquatic insects Biology Cloning Culicidae Culicidae - parasitology Dehydrogenases Dihydrofolate reductase Disease transmission Down-Regulation Evaluation Fluorescence Fluorescence microscopy Gene expression Gene silencing Genes Genes, Reporter - genetics Genetic engineering Genomics Green fluorescent protein Humans Immunology Infections Infectious diseases Infectivity Insect Vectors - parasitology Laboratories Life Sciences Loads (forces) Luciferase Malaria Medicine Mosquitoes Organ Specificity Parasite Load - methods Parasites Parasitology Plasmodium Plasmodium berghei Plasmodium berghei - genetics Plasmodium berghei - physiology Proteins Reporter gene Salivary gland Salivary Glands - parasitology Salivary Proteins and Peptides - deficiency Sporozoites Sporozoites - physiology Time Factors Transgenic Vaccines Vector-borne diseases
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