Interspecific germline transmission of cultured primordial germ cells

In birds, the primordial germ cell (PGC) lineage separates from the soma within 24 h following fertilization. Here we show that the endogenous population of about 200 PGCs from a single chicken embryo can be expanded one million fold in culture. When cultured PGCs are injected into a xenogeneic embr...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e35664-e35664
Hauptverfasser:	van de Lavoir, Marie-Cecile, Collarini, Ellen J, Leighton, Philip A, Fesler, Jeffrey, Lu, Daniel R, Harriman, William D, Thiyagasundaram, T S, Etches, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animals Biology Birds Cell culture Cell Line Cells, Cultured Chimera - genetics Cloning Developmental stages Embryonic development Endangered & extinct species Endangered species Female Females Fertilization Fish Flow cytometry Galliformes - genetics Gallus gallus Gallus gallus domesticus Germ cells Germ Cells - cytology International trade Interspecific Male Males Numida meleagris Offspring Protection and preservation Rodents Semen Sexual maturity Sperm Spermatogenesis Stem cells Toads Veterinary Science Wildlife conservation
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