Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China
Since the late 1970's, time-space clusters of sudden unexplained death (SUD) in northwest Yunnan, China have alarmed the public and health authorities. From 2006-2009, we initiated enhanced surveillance for SUD to identify a cause, and we warned villagers to avoid eating unfamiliar mushrooms. W...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-05, Vol.7 (5), p.e35894 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | e35894 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Shi, Guo-Qing Huang, Wen-Li Zhang, Jian Zhao, Hong Shen, Tao Fontaine, Robert E Yang, Lin Zhao, Su Lu, Bu-Lai Wang, Yue-Bing Ma, Lin Li, Zhao-Xiang Gao, Yang Yang, Zhu-Liang Zeng, Guang |
| description | Since the late 1970's, time-space clusters of sudden unexplained death (SUD) in northwest Yunnan, China have alarmed the public and health authorities. From 2006-2009, we initiated enhanced surveillance for SUD to identify a cause, and we warned villagers to avoid eating unfamiliar mushrooms.
We established surveillance for SUD, defined as follows: sudden onset of serious, unexplained physical impairment followed by death in |
| doi_str_mv | 10.1371/journal.pone.0035894 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1324607783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A477074681</galeid><doaj_id>oai_doaj_org_article_30fbfc9355ab43fc8a96fb44f12fd634</doaj_id><sourcerecordid>A477074681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-42099e6ed95d4dce8b33e90e9b314ea0232edd4060a2ce55d0efbc6ced2bcf1d3</originalsourceid><addsrcrecordid>eNqNkl-L1DAUxYso7rr6DUQDgiDMjGmTptMXYRn8M7CwoqvgU0iTm2mWNplN0nH99mac7jIFBclDkpvfPbkcTpY9z_EiJ1X-9toN3opusXUWFhiTclnTB9lpXpNizgpMHh6dT7InIVxjXJIlY4-zk6JgeVlRcpqFVTeECD4gp1EYlAKLBgu3204YCwopELFFIgQnjYip8NOke2wB9UNovXP9DF15tzEC7cCCFVHMkLHID1506MdgrbDos3c7YyXM0Ko1VjzNHmnRBXg27mfZtw_vr1af5heXH9er84u5ZHUR57TAdQ0MVF0qqiQsG0KgxlA3JKcgcEEKUIpihkUhoSwVBt1IJkEVjdS5ImfZy4PutnOBj34FnpOCMlxVS5KI9YFQTlzzrTe98L-4E4b_KTi_4cJHIzvgBOtGy5qUpWgo0XIpaqYbSnVeaMUITVrvxt-Gpoc0r43Jgono9MWalm_cjpOkmbM8CbwaBby7GSDEf4w8UhuRpjJWuyQmexMkP6dVhSvKlnutxV-otBT0RqbEaJPqk4Y3k4bERLiNGzGEwNdfv_w_e_l9yr4-YlsQXWyD64ZonA1TkB5A6V0IHvS9cznm-8DfucH3gedj4FPbi2PX75vuEk5-A03O_a0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1324607783</pqid></control><display><type>article</type><title>Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Shi, Guo-Qing ; Huang, Wen-Li ; Zhang, Jian ; Zhao, Hong ; Shen, Tao ; Fontaine, Robert E ; Yang, Lin ; Zhao, Su ; Lu, Bu-Lai ; Wang, Yue-Bing ; Ma, Lin ; Li, Zhao-Xiang ; Gao, Yang ; Yang, Zhu-Liang ; Zeng, Guang</creator><contributor>Wormley, Floyd L.</contributor><creatorcontrib>Shi, Guo-Qing ; Huang, Wen-Li ; Zhang, Jian ; Zhao, Hong ; Shen, Tao ; Fontaine, Robert E ; Yang, Lin ; Zhao, Su ; Lu, Bu-Lai ; Wang, Yue-Bing ; Ma, Lin ; Li, Zhao-Xiang ; Gao, Yang ; Yang, Zhu-Liang ; Zeng, Guang ; Wormley, Floyd L.</creatorcontrib><description>Since the late 1970's, time-space clusters of sudden unexplained death (SUD) in northwest Yunnan, China have alarmed the public and health authorities. From 2006-2009, we initiated enhanced surveillance for SUD to identify a cause, and we warned villagers to avoid eating unfamiliar mushrooms.
We established surveillance for SUD, defined as follows: sudden onset of serious, unexplained physical impairment followed by death in <24 hours. A mild case was onset of any illness in a member of the family or close socially related group of a SUD victim within 1 week of a SUD. We interviewed witnesses of SUD and mild case-persons to identify exposures to potentially toxic substances. We tested blood from mild cases, villagers, and for standard biochemical, enzyme, and electrolyte markers of disease.
We identified 33 SUD, a 73% decline from 2002-2005, distributed among 21 villages of 11 counties. We found a previously undescribed mushroom, Trogia venenata, was eaten by 5 of 7 families with SUD clusters compared to 0 of 31 other control-families from the same villages. In T. venenata-exposed persons SUD was characterized by sudden loss of consciousness during normal activities. This mushroom grew nearby 75% of 61 villages that had time-space SUD clusters from 1975 to 2009 compared to 17% of 18 villages with only single SUD (p<0.001, Fisher's exact test).
Epidemiologic data has implicated T. venenata as a probable cause of clusters of SUD in northwestern Yunnan Province. Warnings to villagers about eating this mushroom should continue.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0035894</identifier><identifier>PMID: 22615743</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Agaricales ; Biology ; Cardiomyopathy ; China - epidemiology ; Cluster Analysis ; Clusters ; Coma ; Death ; Disease control ; Disease prevention ; Enzymes ; Epidemiology ; Fatalities ; Humans ; Laboratories ; Medicine ; Mortality ; Mushroom Poisoning - epidemiology ; Mushroom Poisoning - mortality ; Mushrooms ; Poisoning ; Population Surveillance ; Rural Population ; Surveillance ; Toxic substances ; Toxicity testing ; Training ; Villages</subject><ispartof>PloS one, 2012-05, Vol.7 (5), p.e35894</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Shi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Shi et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-42099e6ed95d4dce8b33e90e9b314ea0232edd4060a2ce55d0efbc6ced2bcf1d3</citedby><cites>FETCH-LOGICAL-c692t-42099e6ed95d4dce8b33e90e9b314ea0232edd4060a2ce55d0efbc6ced2bcf1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355161/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355161/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22615743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wormley, Floyd L.</contributor><creatorcontrib>Shi, Guo-Qing</creatorcontrib><creatorcontrib>Huang, Wen-Li</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Zhao, Hong</creatorcontrib><creatorcontrib>Shen, Tao</creatorcontrib><creatorcontrib>Fontaine, Robert E</creatorcontrib><creatorcontrib>Yang, Lin</creatorcontrib><creatorcontrib>Zhao, Su</creatorcontrib><creatorcontrib>Lu, Bu-Lai</creatorcontrib><creatorcontrib>Wang, Yue-Bing</creatorcontrib><creatorcontrib>Ma, Lin</creatorcontrib><creatorcontrib>Li, Zhao-Xiang</creatorcontrib><creatorcontrib>Gao, Yang</creatorcontrib><creatorcontrib>Yang, Zhu-Liang</creatorcontrib><creatorcontrib>Zeng, Guang</creatorcontrib><title>Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Since the late 1970's, time-space clusters of sudden unexplained death (SUD) in northwest Yunnan, China have alarmed the public and health authorities. From 2006-2009, we initiated enhanced surveillance for SUD to identify a cause, and we warned villagers to avoid eating unfamiliar mushrooms.
We established surveillance for SUD, defined as follows: sudden onset of serious, unexplained physical impairment followed by death in <24 hours. A mild case was onset of any illness in a member of the family or close socially related group of a SUD victim within 1 week of a SUD. We interviewed witnesses of SUD and mild case-persons to identify exposures to potentially toxic substances. We tested blood from mild cases, villagers, and for standard biochemical, enzyme, and electrolyte markers of disease.
We identified 33 SUD, a 73% decline from 2002-2005, distributed among 21 villages of 11 counties. We found a previously undescribed mushroom, Trogia venenata, was eaten by 5 of 7 families with SUD clusters compared to 0 of 31 other control-families from the same villages. In T. venenata-exposed persons SUD was characterized by sudden loss of consciousness during normal activities. This mushroom grew nearby 75% of 61 villages that had time-space SUD clusters from 1975 to 2009 compared to 17% of 18 villages with only single SUD (p<0.001, Fisher's exact test).
Epidemiologic data has implicated T. venenata as a probable cause of clusters of SUD in northwestern Yunnan Province. Warnings to villagers about eating this mushroom should continue.</description><subject>Agaricales</subject><subject>Biology</subject><subject>Cardiomyopathy</subject><subject>China - epidemiology</subject><subject>Cluster Analysis</subject><subject>Clusters</subject><subject>Coma</subject><subject>Death</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Fatalities</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Medicine</subject><subject>Mortality</subject><subject>Mushroom Poisoning - epidemiology</subject><subject>Mushroom Poisoning - mortality</subject><subject>Mushrooms</subject><subject>Poisoning</subject><subject>Population Surveillance</subject><subject>Rural Population</subject><subject>Surveillance</subject><subject>Toxic substances</subject><subject>Toxicity testing</subject><subject>Training</subject><subject>Villages</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl-L1DAUxYso7rr6DUQDgiDMjGmTptMXYRn8M7CwoqvgU0iTm2mWNplN0nH99mac7jIFBclDkpvfPbkcTpY9z_EiJ1X-9toN3opusXUWFhiTclnTB9lpXpNizgpMHh6dT7InIVxjXJIlY4-zk6JgeVlRcpqFVTeECD4gp1EYlAKLBgu3204YCwopELFFIgQnjYip8NOke2wB9UNovXP9DF15tzEC7cCCFVHMkLHID1506MdgrbDos3c7YyXM0Ko1VjzNHmnRBXg27mfZtw_vr1af5heXH9er84u5ZHUR57TAdQ0MVF0qqiQsG0KgxlA3JKcgcEEKUIpihkUhoSwVBt1IJkEVjdS5ImfZy4PutnOBj34FnpOCMlxVS5KI9YFQTlzzrTe98L-4E4b_KTi_4cJHIzvgBOtGy5qUpWgo0XIpaqYbSnVeaMUITVrvxt-Gpoc0r43Jgono9MWalm_cjpOkmbM8CbwaBby7GSDEf4w8UhuRpjJWuyQmexMkP6dVhSvKlnutxV-otBT0RqbEaJPqk4Y3k4bERLiNGzGEwNdfv_w_e_l9yr4-YlsQXWyD64ZonA1TkB5A6V0IHvS9cznm-8DfucH3gedj4FPbi2PX75vuEk5-A03O_a0</recordid><startdate>20120517</startdate><enddate>20120517</enddate><creator>Shi, Guo-Qing</creator><creator>Huang, Wen-Li</creator><creator>Zhang, Jian</creator><creator>Zhao, Hong</creator><creator>Shen, Tao</creator><creator>Fontaine, Robert E</creator><creator>Yang, Lin</creator><creator>Zhao, Su</creator><creator>Lu, Bu-Lai</creator><creator>Wang, Yue-Bing</creator><creator>Ma, Lin</creator><creator>Li, Zhao-Xiang</creator><creator>Gao, Yang</creator><creator>Yang, Zhu-Liang</creator><creator>Zeng, Guang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120517</creationdate><title>Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China</title><author>Shi, Guo-Qing ; Huang, Wen-Li ; Zhang, Jian ; Zhao, Hong ; Shen, Tao ; Fontaine, Robert E ; Yang, Lin ; Zhao, Su ; Lu, Bu-Lai ; Wang, Yue-Bing ; Ma, Lin ; Li, Zhao-Xiang ; Gao, Yang ; Yang, Zhu-Liang ; Zeng, Guang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-42099e6ed95d4dce8b33e90e9b314ea0232edd4060a2ce55d0efbc6ced2bcf1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Agaricales</topic><topic>Biology</topic><topic>Cardiomyopathy</topic><topic>China - epidemiology</topic><topic>Cluster Analysis</topic><topic>Clusters</topic><topic>Coma</topic><topic>Death</topic><topic>Disease control</topic><topic>Disease prevention</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Fatalities</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Medicine</topic><topic>Mortality</topic><topic>Mushroom Poisoning - epidemiology</topic><topic>Mushroom Poisoning - mortality</topic><topic>Mushrooms</topic><topic>Poisoning</topic><topic>Population Surveillance</topic><topic>Rural Population</topic><topic>Surveillance</topic><topic>Toxic substances</topic><topic>Toxicity testing</topic><topic>Training</topic><topic>Villages</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Guo-Qing</creatorcontrib><creatorcontrib>Huang, Wen-Li</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Zhao, Hong</creatorcontrib><creatorcontrib>Shen, Tao</creatorcontrib><creatorcontrib>Fontaine, Robert E</creatorcontrib><creatorcontrib>Yang, Lin</creatorcontrib><creatorcontrib>Zhao, Su</creatorcontrib><creatorcontrib>Lu, Bu-Lai</creatorcontrib><creatorcontrib>Wang, Yue-Bing</creatorcontrib><creatorcontrib>Ma, Lin</creatorcontrib><creatorcontrib>Li, Zhao-Xiang</creatorcontrib><creatorcontrib>Gao, Yang</creatorcontrib><creatorcontrib>Yang, Zhu-Liang</creatorcontrib><creatorcontrib>Zeng, Guang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Guo-Qing</au><au>Huang, Wen-Li</au><au>Zhang, Jian</au><au>Zhao, Hong</au><au>Shen, Tao</au><au>Fontaine, Robert E</au><au>Yang, Lin</au><au>Zhao, Su</au><au>Lu, Bu-Lai</au><au>Wang, Yue-Bing</au><au>Ma, Lin</au><au>Li, Zhao-Xiang</au><au>Gao, Yang</au><au>Yang, Zhu-Liang</au><au>Zeng, Guang</au><au>Wormley, Floyd L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-05-17</date><risdate>2012</risdate><volume>7</volume><issue>5</issue><spage>e35894</spage><pages>e35894-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Since the late 1970's, time-space clusters of sudden unexplained death (SUD) in northwest Yunnan, China have alarmed the public and health authorities. From 2006-2009, we initiated enhanced surveillance for SUD to identify a cause, and we warned villagers to avoid eating unfamiliar mushrooms.
We established surveillance for SUD, defined as follows: sudden onset of serious, unexplained physical impairment followed by death in <24 hours. A mild case was onset of any illness in a member of the family or close socially related group of a SUD victim within 1 week of a SUD. We interviewed witnesses of SUD and mild case-persons to identify exposures to potentially toxic substances. We tested blood from mild cases, villagers, and for standard biochemical, enzyme, and electrolyte markers of disease.
We identified 33 SUD, a 73% decline from 2002-2005, distributed among 21 villages of 11 counties. We found a previously undescribed mushroom, Trogia venenata, was eaten by 5 of 7 families with SUD clusters compared to 0 of 31 other control-families from the same villages. In T. venenata-exposed persons SUD was characterized by sudden loss of consciousness during normal activities. This mushroom grew nearby 75% of 61 villages that had time-space SUD clusters from 1975 to 2009 compared to 17% of 18 villages with only single SUD (p<0.001, Fisher's exact test).
Epidemiologic data has implicated T. venenata as a probable cause of clusters of SUD in northwestern Yunnan Province. Warnings to villagers about eating this mushroom should continue.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22615743</pmid><doi>10.1371/journal.pone.0035894</doi><tpages>e35894</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-05, Vol.7 (5), p.e35894 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1324607783 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Agaricales Biology Cardiomyopathy China - epidemiology Cluster Analysis Clusters Coma Death Disease control Disease prevention Enzymes Epidemiology Fatalities Humans Laboratories Medicine Mortality Mushroom Poisoning - epidemiology Mushroom Poisoning - mortality Mushrooms Poisoning Population Surveillance Rural Population Surveillance Toxic substances Toxicity testing Training Villages |
| title | Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T07%3A00%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clusters%20of%20sudden%20unexplained%20death%20associated%20with%20the%20mushroom,%20Trogia%20venenata,%20in%20rural%20Yunnan%20Province,%20China&rft.jtitle=PloS%20one&rft.au=Shi,%20Guo-Qing&rft.date=2012-05-17&rft.volume=7&rft.issue=5&rft.spage=e35894&rft.pages=e35894-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0035894&rft_dat=%3Cgale_plos_%3EA477074681%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1324607783&rft_id=info:pmid/22615743&rft_galeid=A477074681&rft_doaj_id=oai_doaj_org_article_30fbfc9355ab43fc8a96fb44f12fd634&rfr_iscdi=true |