Induction of cellular senescence by doxorubicin is associated with upregulated miR-375 and induction of autophagy in K562 cells

Cellular senescence is a specialized form of growth arrest that is generally irreversible. Upregulated p16, p53, and p21 expression and silencing of E2F target genes have been characterized to promote the establishment of senescence. It can be further aided by the transcriptional repression of proli...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e37205
Hauptverfasser:	Yang, Ming-Yu, Lin, Pai-Mei, Liu, Yi-Chang, Hsiao, Hui-Hua, Yang, Wen-Chi, Hsu, Jui-Feng, Hsu, Cheng-Ming, Lin, Sheng-Fung
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - genetics Aging Aging (natural) Analysis Anthracyclines Apoptosis Autophagy Autophagy - drug effects Biology Cell cycle Cell death Cell growth Cell proliferation Cellular Senescence - drug effects Cellular Senescence - genetics Cellular Senescence - physiology Cervical cancer Chromatin Chromosomal proteins Dehydrogenases Development and progression Doxorubicin Doxorubicin - pharmacology E2F protein Esophageal cancer Gastric cancer Gene expression Gene silencing Genes Genes, p16 Genes, p53 Genetic aspects Hematology Hospitals Humans Insulin-like growth factors Internal medicine K562 Cells Kinases Liver cancer Medicine Metastasis MicroRNA MicroRNAs MicroRNAs - genetics miRNA Models, Biological Morphology Oncology p53 Protein Phagocytosis Proteins Ribonucleic acid RNA Senescence Sp1 protein Sp1 Transcription Factor - genetics Stomach cancer Transcription (Genetics) Transcription factors Tumor proteins Tumor suppression Up-Regulation - drug effects
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