Congenital amusia persists in the developing brain after daily music listening

Congenital amusia is a neurodevelopmental disorder that affects about 3% of the adult population. Adults experiencing this musical disorder in the absence of macroscopically visible brain injury are described as cases of congenital amusia under the assumption that the musical deficits have been pres...

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Veröffentlicht in:PloS one 2012-05, Vol.7 (5), p.e36860-e36860
Hauptverfasser: Mignault Goulet, Geneviève, Moreau, Patricia, Robitaille, Nicolas, Peretz, Isabelle
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Moreau, Patricia
Robitaille, Nicolas
Peretz, Isabelle
description Congenital amusia is a neurodevelopmental disorder that affects about 3% of the adult population. Adults experiencing this musical disorder in the absence of macroscopically visible brain injury are described as cases of congenital amusia under the assumption that the musical deficits have been present from birth. Here, we show that this disorder can be expressed in the developing brain. We found that (10-13 year-old) children exhibit a marked deficit in the detection of fine-grained pitch differences in both musical and acoustical context in comparison to their normally developing peers comparable in age and general intelligence. This behavioral deficit could be traced down to their abnormal P300 brain responses to the detection of subtle pitch changes. The altered pattern of electrical activity does not seem to arise from an anomalous functioning of the auditory cortex, because all early components of the brain potentials, the N100, the MMN, and the P200 appear normal. Rather, the brain and behavioral measures point to disrupted information propagation from the auditory cortex to other cortical regions. Furthermore, the behavioral and neural manifestations of the disorder remained unchanged after 4 weeks of daily musical listening. These results show that congenital amusia can be detected in childhood despite regular musical exposure and normal intellectual functioning.
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subjects Adults
Auditory Cortex - growth & development
Auditory Cortex - physiopathology
Auditory evoked potentials
Auditory Pathways - physiopathology
Auditory Perception
Auditory Perceptual Disorders - physiopathology
Auditory Perceptual Disorders - psychology
Auditory Perceptual Disorders - therapy
Biology
Brain
Brain injuries
Brain injury
Brain research
Case-Control Studies
Child
Children
Cognitive ability
Congenital diseases
Cooperation
Cortex (auditory)
Dyslexia
Electric properties
Event-related potentials
Evoked Potentials, Auditory
Female
Frequency
Genetic disorders
Head injuries
Humans
Intelligence
Laboratories
Listening
Male
Medicine
Melody
Mismatch negativity
Music
Music Therapy
Neurodevelopmental disorders
Neurosciences
NMR
Nuclear magnetic resonance
Pitch Discrimination
Pitch Perception
Psychology
Social and Behavioral Sciences
Sound
Trends
title Congenital amusia persists in the developing brain after daily music listening
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