Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation

Silencing of genes by hypermethylation contributes to cancer progression and has been shown to occur with increased frequency at specific genomic loci. However, the precise mechanisms underlying the establishment and maintenance of aberrant methylation marks are still elusive. The de novo DNA methyl...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36125-e36125
Hauptverfasser:	Hagemann, Sabine, Kuck, Dirk, Stresemann, Carlo, Prinz, Florian, Brueckner, Bodo, Mund, Cora, Mumberg, Dominik, Sommer, Anette
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activation Analysis Antiproliferatives Apoptosis Arrays Biology Biotechnology Caco-2 Cells Cancer Cancer research Cell Line Cell Line, Tumor Cell Proliferation Cell Survival - genetics Colon Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Demethylation Deoxyribonucleic acid Depletion Development and progression DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA fingerprinting DNA Methylation DNA methyltransferase DNA Methyltransferase 3B Drug development Drugs Epigenetic inheritance Epigenetics Gene amplification Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene silencing Genes Genetic aspects Genomes Genomics HCT116 Cells HT29 Cells Humans Immunoblotting Medical research Medicine Methylation Methyltransferases Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Pharmaceuticals Proteins Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA Interference RNA-mediated interference Stress response Studies Tumor cell lines Tumor suppressor genes Tumors
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