Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes

The insulin (INS) region is the second most important locus associated with Type 1 Diabetes (T1D). The study of the DNA methylation pattern of the 7 CpGs proximal to the TSS in the INS gene promoter revealed that T1D patients have a lower level of methylation of CpG -19, -135 and -234 (p = 2.10(-16)...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36278
Hauptverfasser:	Fradin, Delphine, Le Fur, Sophie, Mille, Clémence, Naoui, Nadia, Groves, Chris, Zelenika, Diana, McCarthy, Mark I, Lathrop, Mark, Bougnères, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Apoptosis Biochemistry, Molecular Biology Biology Biomarkers Child Colorectal cancer CpG islands Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - genetics Dinucleoside Phosphates - genetics DNA DNA methylation DNA Methylation - genetics Endocrinology Endocrinology and metabolism Epigenetic inheritance Epigenetics Female Gene expression Genes Genetic aspects Genomes Glucose Glycosylated hemoglobin Haplotypes Hemoglobin Human health and pathology Humans Hyperglycemia INS gene Insulin Insulin - genetics Life Sciences Loci Male Medical diagnosis Medicine Metabolism Methylation Molecular biology Obesity Patients Pediatrics Population (statistical) Promoter Regions, Genetic - genetics Promoters Single-nucleotide polymorphism Statistics Studies Type 1 diabetes Type 2 diabetes
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