Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice

The zoonotic pathogen Campylobacter jejuni is a leading cause of bacterial foodborne enterocolitis in humans worldwide. The understanding of immunopathology underlying human campylobacteriosis is hampered by the fact that mice display strong colonization resistance against the pathogen due to their...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e35988-e35988
Hauptverfasser:	Haag, Lea-Maxie, Fischer, André, Otto, Bettina, Plickert, Rita, Kühl, Anja A, Göbel, Ulf B, Bereswill, Stefan, Heimesaat, Markus M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Bacteria Bacterial Translocation - immunology Bacterial Translocation - physiology Bacteroides Biology Blood Campylobacter Campylobacter fetus Campylobacter Infections - genetics Campylobacter Infections - immunology Campylobacter Infections - microbiology Campylobacter jejuni Campylobacter jejuni - growth & development Campylobacter jejuni - immunology Campylobacter jejuni - physiology Campylobacteriosis Colitis Colitis - genetics Colitis - immunology Colitis - microbiology Colon - immunology Colon - metabolism Colon - microbiology Colonization Commensals Cytokines Diarrhea Digestive tract Disease E coli Enterobacteriaceae Enterocolitis Epidemiology Escherichia coli Escherichia coli - growth & development Escherichia coli - immunology Escherichia coli - physiology Feces - microbiology Feeding Fetuses Food Gram-negative bacteria Health risks Host-Pathogen Interactions - immunology Humans Hygiene Ileitis Ileitis - etiology Ileitis - immunology Ileitis - microbiology Immunology Infants Infection Infections Inflammation Inflammation Mediators - immunology Inflammation Mediators - metabolism Inflammatory bowel disease Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-10 - deficiency Interleukin-10 - genetics Interleukin-10 - immunology Intestinal microflora Intestine Intestines - immunology Intestines - microbiology Irritable bowel syndrome Kidney Kidneys Liver Load resistance Loads (forces) Medicine Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Microbial drug resistance Microbiota Microbiota (Symbiotic organisms) Mimicry Molecular modelling Pathogenesis Pathogens Physiological aspects Resistance factors Risk analysis Risk factors Rodents Salmonella Spleen Time Factors Toxoplasma Toxoplasma gondii Toxoplasmosis, Animal - complications Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Zoonoses
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