Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis

Multiple sclerosis (MS) is a complex disease of the central nervous system of unknown etiology. The human leukocyte antigen (HLA) locus on chromosome 6 confers a considerable part of the susceptibility to MS, and the most important factor is the class II allele HLA-DRB1*15:01. In addition, we and ot...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36779-e36779
Hauptverfasser:	Link, Jenny, Kockum, Ingrid, Lorentzen, Aslaug R, Lie, Benedicte A, Celius, Elisabeth G, Westerlind, Helga, Schaffer, Marie, Alfredsson, Lars, Olsson, Tomas, Brynedal, Boel, Harbo, Hanne F, Hillert, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Antigens Autoimmune diseases Biology Central nervous system Chromosome 6 Clinical medicine Confidence intervals Drb1 protein Epidemiology Etiology Female Genes Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Haplotypes Histocompatibility antigen HLA HLA antigens HLA-A Antigens - genetics HLA-B Antigens - genetics HLA-DRB1 Chains - genetics Hospitals Humans Immunology Influence Leukocytes Linkage Disequilibrium Male Medicine Middle Aged Multiple sclerosis Multiple Sclerosis - genetics Neurology Neurosciences Polymorphism, Single Nucleotide Regression analysis Risk Scandinavian and Nordic Countries Studies
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