Dysregulated recruitment of the histone methyltransferase EZH2 to the class II transactivator (CIITA) promoter IV in breast cancer cells

One mechanism frequently utilized by tumor cells to escape immune system recognition and elimination is suppression of cell surface expression of Major Histocompatibility Class II (MHC II) molecules. Expression of MHC II is regulated primarily at the level of transcription by the Class II Transactiv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e36013-e36013
Hauptverfasser:	Truax, Agnieszka D, Thakkar, Meghna, Greer, Susanna F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Antigens B cells Base Sequence Biological response modifiers Biology Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Line, Tumor Cell surface Chromatin CIITA protein Cytokines Cytotoxicity DNA methylation DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer of Zeste Homolog 2 Protein Epigenetic inheritance Epigenetics Escape systems Female Gene expression Gene silencing Genes Histocompatibility antigen HLA Histone H3 Histone methyltransferase Histones Histones - metabolism HLA antigens HLA-DR alpha-Chains - genetics HLA-DR alpha-Chains - metabolism Homology Humans Immune system Interferon Interferon-gamma - metabolism Interferon-gamma - pharmacology Kinases Lymphocytes Lysine Major histocompatibility complex Melanoma Metastasis Methylation - drug effects Methyltransferases Molecular biology Molecular Sequence Data Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiology Polycomb Repressive Complex 2 Promoter Regions, Genetic Prostate cancer Protein Binding Proteins RNA RNA Interference RNA, Small Interfering - metabolism Stimulation Studies Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Tumor cells Tumors γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!