Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever

Ebola virus (EBOV) is the causative agent of severe hemorrhagic fever in primates, with human case fatality rates up to 90%. Today, there is neither a licensed vaccine nor a treatment available for Ebola hemorrhagic fever (EHF). Single monoclonal antibodies (MAbs) specific for Zaire ebolavirus (ZEBO...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e36192-e36192
Hauptverfasser:	Marzi, Andrea, Yoshida, Reiko, Miyamoto, Hiroko, Ishijima, Mari, Suzuki, Yasuhiko, Higuchi, Megumi, Matsuyama, Yukie, Igarashi, Manabu, Nakayama, Eri, Kuroda, Makoto, Saijo, Masayuki, Feldmann, Friederike, Brining, Douglas, Feldmann, Heinz, Takada, Ayato
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Amino acids Analysis Animal diseases Animal models Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Antibody Specificity Biology Blood circulation Cercopithecus aethiops CHO Cells Cricetinae Cricetulus Cytotoxicity Disease Models, Animal Ebola hemorrhagic fever Ebola virus Ebolavirus Ebolavirus - immunology Ebolavirus - pathogenicity Ebolavirus - physiology Encephalitis Enzymes Epidemics Epidemiology Epitopes - immunology Extremely high frequencies Fatalities Fever Glycoproteins Health aspects Hemorrhage Hemorrhagic fever Hemorrhagic Fever, Ebola - prevention & control Humans Immunization Immunization, Passive Immunoglobulin G Immunoglobulins Infectious diseases Laboratories Macaca mulatta Male Marburg virus disease Medical research Medicine Mice Models, Molecular Monoclonal antibodies Neutralizing Operations management Pathogenesis Primates Protection and preservation Protein Conformation Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - immunology Swine flu Trends Vaccines Vero Cells Veterinary Science Viral diseases Viral Load - immunology Viremia Virology Virus diseases Viruses Wildlife conservation Zoonoses
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