Regulatory effect of connexin 43 on basal Ca2+ signaling in rat ventricular myocytes

It has been found that gap junction-associated intracellular Ca(2+) [Ca(2+)](i) disturbance contributes to the arrhythmogenesis and hyperconstriction in diseased heart. However, whether functional gaps are also involved in the regulation of normal Ca(2+) signaling, in particular the basal [Ca(2+)](i...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e36165-e36165
Hauptverfasser:	Li, Chen, Meng, Qingli, Yu, Xinfeng, Jing, Xian, Xu, Pingxiang, Luo, Dali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Agonists - pharmacology Adrenergic receptors Animals Biology Calcium (intracellular) Calcium - metabolism Calcium influx Calcium permeability Calcium Signaling Calcium signalling Cardiac muscle Cardiomyocytes Cell Communication - drug effects Cell growth Cells, Cultured Connexin 43 Connexin 43 - antagonists & inhibitors Connexin 43 - genetics Connexin 43 - metabolism Coronary artery disease Coupling Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Gap junctions Gap Junctions - metabolism Heart Heart diseases Heart failure Heart Ventricles - cytology HEK293 Cells Humans Immunoblotting Inositol 1,4,5-Trisphosphate - pharmacology Inositol 1,4,5-trisphosphate receptors Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors Inositol 1,4,5-Trisphosphate Receptors - metabolism Isoquinolines - chemistry Isoquinolines - metabolism Kinases Medicine Metabolism Myocytes Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Neonates Permeability Pharmaceutical sciences Pharmacology Phenylephrine Phenylephrine - pharmacology Rats Rats, Sprague-Dawley Receptors, Adrenergic - chemistry Receptors, Adrenergic - metabolism RNA Interference RNA, Small Interfering - metabolism Rodents siRNA Uncouplers Ventricle Xestospongin C
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