Nuclear distributions of NUP62 and NUP214 suggest architectural diversity and spatial patterning among nuclear pore complexes
The shape of nuclei in many adherent cultured cells approximates an oblate ellipsoid, with contralateral flattened surfaces facing the culture plate or the medium. Observations of cultured cell nuclei from orthogonal perspectives revealed that nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are...
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| Veröffentlicht in: | PloS one 2012-04, Vol.7 (4), p.e36137 |
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| creator | Kinoshita, Yayoi Kalir, Tamara Dottino, Peter Kohtz, D Stave |
| description | The shape of nuclei in many adherent cultured cells approximates an oblate ellipsoid, with contralateral flattened surfaces facing the culture plate or the medium. Observations of cultured cell nuclei from orthogonal perspectives revealed that nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes on the flattened surfaces and peripheral rim of the nucleus. High resolution stimulated emission depletion (STED) immunofluorescence microscopy resolved individual NPCs, and suggested both heterogeneity and microheterogeneity in NUP62 and NUP214 immunolabeling among in NPC populations. Similar to nuclear domains and interphase chromosome territories, architectural diversity and spatial patterning of NPCs may be an intrinsic property of the nucleus that is linked to the functions and organization of underlying chromatin. |
| doi_str_mv | 10.1371/journal.pone.0036137 |
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Observations of cultured cell nuclei from orthogonal perspectives revealed that nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes on the flattened surfaces and peripheral rim of the nucleus. High resolution stimulated emission depletion (STED) immunofluorescence microscopy resolved individual NPCs, and suggested both heterogeneity and microheterogeneity in NUP62 and NUP214 immunolabeling among in NPC populations. Similar to nuclear domains and interphase chromosome territories, architectural diversity and spatial patterning of NPCs may be an intrinsic property of the nucleus that is linked to the functions and organization of underlying chromatin.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0036137</identifier><identifier>PMID: 22558357</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology ; Cell Compartmentation ; Cell Count ; Cell culture ; Cell Line, Tumor ; Cell Nucleus Shape ; Chromatin ; Cloning ; Cytoplasm ; Drosophila ; Epigenetics ; Female ; Gene Knockdown Techniques ; Humans ; Immunofluorescence ; Insects ; Medicine ; Membrane Glycoproteins - metabolism ; Microheterogeneity ; Microscopy ; Microscopy, Fluorescence ; Neuroblastoma ; Nuclear Pore - metabolism ; Nuclear Pore Complex Proteins - metabolism ; Nuclei ; Nuclei (cytology) ; Ovarian cancer ; Ovarian Neoplasms - metabolism ; Pathology ; Porins ; Protein Transport ; Proteins ; RNA, Small Interfering - metabolism ; Spatial distribution ; Staining and Labeling ; Stimulated emission ; Throat cancer ; Transfection ; Trends</subject><ispartof>PloS one, 2012-04, Vol.7 (4), p.e36137</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Kinoshita et al. 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Observations of cultured cell nuclei from orthogonal perspectives revealed that nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes on the flattened surfaces and peripheral rim of the nucleus. High resolution stimulated emission depletion (STED) immunofluorescence microscopy resolved individual NPCs, and suggested both heterogeneity and microheterogeneity in NUP62 and NUP214 immunolabeling among in NPC populations. 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Observations of cultured cell nuclei from orthogonal perspectives revealed that nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes on the flattened surfaces and peripheral rim of the nucleus. High resolution stimulated emission depletion (STED) immunofluorescence microscopy resolved individual NPCs, and suggested both heterogeneity and microheterogeneity in NUP62 and NUP214 immunolabeling among in NPC populations. Similar to nuclear domains and interphase chromosome territories, architectural diversity and spatial patterning of NPCs may be an intrinsic property of the nucleus that is linked to the functions and organization of underlying chromatin.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22558357</pmid><doi>10.1371/journal.pone.0036137</doi><tpages>e36137</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biology Cell Compartmentation Cell Count Cell culture Cell Line, Tumor Cell Nucleus Shape Chromatin Cloning Cytoplasm Drosophila Epigenetics Female Gene Knockdown Techniques Humans Immunofluorescence Insects Medicine Membrane Glycoproteins - metabolism Microheterogeneity Microscopy Microscopy, Fluorescence Neuroblastoma Nuclear Pore - metabolism Nuclear Pore Complex Proteins - metabolism Nuclei Nuclei (cytology) Ovarian cancer Ovarian Neoplasms - metabolism Pathology Porins Protein Transport Proteins RNA, Small Interfering - metabolism Spatial distribution Staining and Labeling Stimulated emission Throat cancer Transfection Trends |
| title | Nuclear distributions of NUP62 and NUP214 suggest architectural diversity and spatial patterning among nuclear pore complexes |
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