Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia

While hybridization based analysis of the cortical transcriptome has provided important insight into the neuropathology of schizophrenia, it represents a restricted view of disease-associated gene activity based on predetermined probes. By contrast, sequencing technology can provide un-biased analys...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e36351-e36351
Hauptverfasser:	Wu, Jing Qin, Wang, Xi, Beveridge, Natalie J, Tooney, Paul A, Scott, Rodney J, Carr, Vaughan J, Cairns, Murray J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alternative splicing Alternative Splicing - genetics Analysis Base Sequence Biology Biosynthesis Brain research Case-Control Studies Cerebral Cortex - metabolism Cerebral Cortex - pathology Cortex DNA probes Doublecortin protein Exons Functional groups Gene expression Gene Expression Profiling Gene sequencing Genes Genomes Genomics Humans Hybridization Intracellular Signaling Peptides and Proteins - genetics Isoforms Kinases Male Medical research Medicine Mental disorders Mental health MicroRNAs Middle Aged Neurosciences Neurotransmission Ontology Pharmacy Promoter Regions, Genetic - genetics Protein-Serine-Threonine Kinases - genetics Proteins Psychiatry Reproducibility of Results Ribonucleic acid RNA RNA Isoforms - genetics RNA sequencing RNA, Messenger - genetics Schizophrenia Schizophrenia - genetics Sequence Analysis, RNA Social and Behavioral Sciences Splicing Studies Superior temporal gyrus Synapses - genetics Technology assessment Temporal gyrus Transcription Transcription (Genetics) Young Adult
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