Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death

Multiple Myeloma (MM) is a lymphatic neoplasm characterized by clonal proliferation of malignant plasma cell that eventually develops resistance to chemotherapy. Drug resistance, differentiation block and increased survival of the MM tumor cells result from high genomic instability. Chromosomal tran...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e33856
Hauptverfasser:	Josefsberg Ben-Yehoshua, Liat, Beider, Katia, Shimoni, Avichai, Ostrovsky, Olga, Samookh, Michal, Peled, Amnon, Nagler, Arnon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Analysis Apoptosis Apoptosis - drug effects B cells Biochemistry Biology Blood proteins Bone marrow Breast cancer Cell activation Cell culture Cell cycle Cell death Cell growth Cell Line, Tumor Cell survival Chemotherapy Chromosome translocations Chronic lymphocytic leukemia Cyclin D Cyclin D1 - metabolism Cyclin E Cyclin E - genetics Cyclin E - metabolism Cyclin-dependent kinase Drug resistance Flavonoids Flavopiridol Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene Silencing Genomic instability Genomic Instability - genetics Genomic Instability - physiology Hematology Humans Kinases Leukemia Mcl-1 protein Medical prognosis Medicine Multiple myeloma Multiple Myeloma - genetics Multiple Myeloma - metabolism Oncogene Proteins - genetics Oncogene Proteins - metabolism Phosphorylation Piperidines Protein Kinase Inhibitors - pharmacology Proteins Purines - pharmacology RNA, Small Interfering - genetics Sensitivity siRNA Stability Stroma Tumor cells Tumorigenesis Tumors
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