Analysis of Tp53 codon 72 polymorphisms, Tp53 mutations, and HPV infection in cutaneous squamous cell carcinomas

Non-melanoma skin cancers are one of the most common human malignancies accounting for 2-3% of tumors in the US and represent a significant health burden. Epidemiology studies have implicated Tp53 mutations triggered by UV exposure, and human papilloma virus (HPV) infection to be significant causes...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e34422-e34422
Hauptverfasser:	Loeb, Keith R, Asgari, Maryam M, Hawes, Stephen E, Feng, Qinghua, Stern, Joshua E, Jiang, Mingjun, Argenyi, Zsolt B, de Villiers, Ethel-Michele, Kiviat, Nancy B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alleles Analysis Apoptosis Biology Cancer Cancer research Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Clinical outcomes Codon Codons Deoxyribonucleic acid Dermatology DNA DNA, Viral - isolation & purification Epidemiology Female Genes Genetic aspects Genotype Health aspects Heterozygosity Human papillomavirus Humans Infection Infections Ionizing radiation Laboratories Lung cancer Medical research Medicine Melanoma Mutation p53 Protein Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus infections Papillomavirus Infections - complications Papillomavirus Infections - diagnosis Pathogenesis Pathology Patients Polymorphism Polymorphism, Genetic Prostate cancer Risk factors Sexually transmitted diseases Skin Skin - pathology Skin - virology Skin cancer Skin diseases Skin Neoplasms - genetics Skin Neoplasms - pathology Skin Neoplasms - virology Squamous cell carcinoma Studies Tumor proteins Tumor Suppressor Protein p53 - genetics Tumors Ultraviolet radiation Viruses
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