Overexpression of angiopoietin-1 increases CD133+/c-kit+ cells and reduces myocardial apoptosis in db/db mouse infarcted hearts

Hematopoietic progenitor CD133(+)/c-kit(+) cells have been shown to be involved in myocardial healing following myocardial infarction (MI). Previously we demonstrated that angiopoietin-1(Ang-1) is beneficial in the repair of diabetic infarcted hearts. We now investigate whether Ang-1 affects CD133(+...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35905
Hauptverfasser:	Zeng, Heng, Li, Lanfang, Chen, Jian-Xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Actins - metabolism Adenoviruses Adipokines Advertising executives Angiogenesis Angiopoietin Angiopoietin-1 - metabolism Animals Antigens, CD - metabolism Apelin Apoptosis Biology Bone marrow Bone Marrow - metabolism Bone Marrow - pathology c-Kit protein Calcium-Binding Proteins - metabolism Capillaries - metabolism Capillaries - pathology Capillaries - physiopathology Cardiomegaly - complications Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - physiopathology Cardiovascular disease Cell growth Cell Movement Chemokine CXCL12 - metabolism Coronary artery Coronary vessels Data recovery Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetic retinopathy Endomyocardial Fibrosis - complications Endomyocardial Fibrosis - metabolism Endomyocardial Fibrosis - pathology Endomyocardial Fibrosis - physiopathology Fibrosis Glycoproteins - metabolism Heart Heart attack Heart attacks Heart diseases Heart Function Tests Hematopoietic Stem Cells - cytology Hemopoiesis Immunoglobulins Intercellular Signaling Peptides and Proteins - metabolism Ischemia Jagged-1 Protein Laboratory animals Medicine Membrane Proteins - metabolism Mice Muscles Myocardial infarction Myocardial Infarction - complications Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardium Myocardium - metabolism Myocardium - pathology Ostomy Peptides - metabolism Pharmacology Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Proto-Oncogene Proteins c-kit - metabolism Receptor, Notch3 Receptors, CXCR4 - metabolism Receptors, Notch - metabolism Recovery of function Recruitment Repair Rodents Serrate-Jagged Proteins Signal Transduction Smooth muscle Stem cells Studies Toxicology Up-Regulation Vascular endothelial growth factor
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