Androgens contribute to sex differences in myocardial remodeling under pressure overload by a mechanism involving TGF-β

In clinical studies, myocardial remodeling in aortic valve stenosis appears to be more favorable in women than in men, even after menopause. In the present study, we assessed whether circulating androgens contribute to a less favorable myocardial remodeling under pressure overload in males. We exami...

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Veröffentlicht in:	PloS one 2012, Vol.7 (4), p.e35635
Hauptverfasser:	Montalvo, Cecilia, Villar, Ana V, Merino, David, García, Raquel, Ares, Miguel, Llano, Miguel, Cobo, Manuel, Hurlé, María A, Nistal, J Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Androgens Androgens - blood Androgens - pharmacology Animals Antibodies - administration & dosage Aorta Aorta - metabolism Aorta - pathology Aortic valve Atherosclerosis Biology Blood Pressure - drug effects Cardiac Myosins - genetics Cardiac Myosins - metabolism Cardiomyocytes Cell growth Cells, Cultured Chains Collagen Collagen - genetics Collagen - metabolism Constriction Coronary vessels Dihydrotestosterone Echocardiography Estrogens Extracellular matrix Female Females Fibroblasts Fibronectin Fibronectins - genetics Fibronectins - metabolism Fibrosis Fibrosis - metabolism Fibrosis - pathology Gender aspects Gene expression Gene Expression - drug effects Heart diseases Heart failure Humans Hypertension Immunoassay Laboratory animals Male Males Medicine Menopause Mens health Metabolism Mice mRNA Myocardium Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Myosin Orchiectomy Pressure Rheumatic heart disease Rodents Sex Sex Characteristics Sex differences Smad Proteins - genetics Smad Proteins - metabolism Smad2 protein Stenosis Testosterone Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Ventricular Remodeling - drug effects Young adults
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