Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo

While natural CD4(+)Foxp3(+) regulatory T (nT(REG)) cells have long been viewed as a stable and distinct lineage that is committed to suppressive functions in vivo, recent evidence supporting this notion remains highly controversial. We sought to determine whether Foxp3 expression and the nT(REG) ce...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35572
Hauptverfasser:	Yurchenko, Ekaterina, Shio, Marina T, Huang, Tony C, Da Silva Martins, Maria, Szyf, Moshe, Levings, Megan K, Olivier, Martin, Piccirillo, Ciriaco A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology CD4 antigen CD4 Antigens - immunology Departments Down-Regulation Effector cells Forkhead Transcription Factors - genetics Forkhead Transcription Factors - immunology Foxp3 protein Functional plasticity Gene Expression - drug effects Genotype & phenotype Growth factors Helper cells Homeostasis Immunity Immunology Immunoregulation Immunosuppressive agents Immunosuppressive Agents - pharmacology Inflammation Inflammation - genetics Inflammation - immunology Inhibition Interleukin 17 Interleukin 2 Interleukin-17 - immunology Interleukin-2 - immunology Intestinal microflora Intestines - immunology Intestines - metabolism Intestines - parasitology Kinases Laboratories Leishmania major Lymphocytes Lymphocytes T Lymphopenia - genetics Lymphopenia - immunology Medicine Mice Mice, Inbred C57BL Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Organs Parasitic diseases Pharmacology Promoter Regions, Genetic Rapamycin Rodents Signaling Sirolimus - pharmacology Studies T cell receptors T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th1 Cells - immunology Th1 Cells - pathology Th17 Cells - immunology Th17 Cells - pathology Thymus TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - immunology Transcription factors
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