Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling

Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses. Defining the role of Ccl2-Ccr2 and Cx3cl1-Cx3cr1 signalling for retinal pathology is of particular interest because of its potential r...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35551
Hauptverfasser:	Luhmann, Ulrich F O, Lange, Clemens A, Robbie, Scott, Munro, Peter M G, Cowing, Jill A, Armer, Hannah E J, Luong, Vy, Carvalho, Livia S, MacLaren, Robert E, Fitzke, Frederick W, Bainbridge, James W B, Ali, Robin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age related diseases Aging Animals Apoptosis Archives & records Atherosclerosis Autosomal recessive inheritance Biology Biomedical research CCR2 protein Chemokine CCL2 - genetics Chemokine CCL2 - immunology Chemokines CRB1 gene CX3C Chemokine Receptor 1 CX3CR1 protein Cytokines Defects Dendritic cells Diabetes Diabetic retinopathy Female Genetics Genotype House mouse Lesions Light Macrophages Macular degeneration Male Medicine Mice Mice, Inbred C57BL Mice, Knockout Microglia Modulation Monocyte chemoattractant protein 1 Mutation Neovascularization Nerve Tissue Proteins - genetics Nervous system Neurotoxicity Ophthalmology Photoreceptors Physiological aspects Protein expression Proteins Receptors, Chemokine - genetics Receptors, Chemokine - immunology Retina Retina - immunology Retina - metabolism Retina - pathology Retinal degeneration Retinal Degeneration - genetics Retinal Degeneration - immunology Retinal Degeneration - pathology Science Signal transduction Signaling
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