Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes

Drug efflux transporters in the placenta can significantly influence the materno-fetal transfer of a diverse array of drugs and other xenobiotics. To determine if clinically important drug efflux transporter expression is altered in pregnancies complicated by gestational diabetes mellitus (GDM-I) or...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35027-e35027
Hauptverfasser:	Anger, Gregory J, Cressman, Alex M, Piquette-Miller, Micheline
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Analysis of Variance ATP Binding Cassette Transporter, Sub-Family B ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism BCRP protein Biology Blotting, Western Breast cancer Cytochrome Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - metabolism Diabetes therapy Diabetes, Gestational - metabolism DNA Primers - genetics DNA, Complementary - biosynthesis Drug dosages Drugs Efflux Enzymes Female Fetuses Gene expression Gene Expression Regulation - physiology Gestational diabetes Glucose Glycated Hemoglobin A - metabolism Glycosylated hemoglobin Hemoglobin HIV Hospitals Human immunodeficiency virus Humans Hyperglycemia Insulin Localization MDR1 protein Medicine Metabolism Metabolites Microbial drug resistance Multidrug resistance Multidrug Resistance-Associated Proteins - metabolism Neoplasm Proteins - metabolism Obstetrics Ontario P-Glycoprotein Patients Pharmaceutical sciences Pharmacology Pharmacy Placenta Placenta - metabolism Polymerase chain reaction Pregnancy Proteins Real-Time Polymerase Chain Reaction RNA Rodents Toxicology Tumors Type 1 diabetes Type 2 diabetes Western blotting Womens health Xenobiotics
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