Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes
Drug efflux transporters in the placenta can significantly influence the materno-fetal transfer of a diverse array of drugs and other xenobiotics. To determine if clinically important drug efflux transporter expression is altered in pregnancies complicated by gestational diabetes mellitus (GDM-I) or...
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| description | Drug efflux transporters in the placenta can significantly influence the materno-fetal transfer of a diverse array of drugs and other xenobiotics. To determine if clinically important drug efflux transporter expression is altered in pregnancies complicated by gestational diabetes mellitus (GDM-I) or type 1 diabetes mellitus (T1DM-I), we compared the expression of multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 2 (MRP2) and the breast cancer resistance protein (BCRP) via western blotting and quantitative real-time polymerase chain reaction in samples obtained from insulin-managed diabetic pregnancies to healthy term-matched controls. At the level of mRNA, we found significantly increased expression of MDR1 in the GDM-I group compared to both the T1DM-I (p |
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To determine if clinically important drug efflux transporter expression is altered in pregnancies complicated by gestational diabetes mellitus (GDM-I) or type 1 diabetes mellitus (T1DM-I), we compared the expression of multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 2 (MRP2) and the breast cancer resistance protein (BCRP) via western blotting and quantitative real-time polymerase chain reaction in samples obtained from insulin-managed diabetic pregnancies to healthy term-matched controls. At the level of mRNA, we found significantly increased expression of MDR1 in the GDM-I group compared to both the T1DM-I (p<0.01) and control groups (p<0.05). Significant changes in the placental protein expression of MDR1, MRP2, and BCRP were not detected (p>0.05). Interestingly, there was a significant, positive correlation observed between plasma hemoglobin A1c levels (a retrospective marker of glycemic control) and both BCRP protein expression (r = 0.45, p<0.05) and BCRP mRNA expression (r = 0.58, p<0.01) in the insulin-managed DM groups. Collectively, the data suggest that the expression of placental efflux transporters is not altered in pregnancies complicated by diabetes when hyperglycemia is managed; however, given the relationship between BCRP expression and plasma hemoglobin A1c levels it is plausible that their expression could change in poorly managed diabetes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0035027</identifier><identifier>PMID: 22558111</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>ABC transporters ; Analysis of Variance ; ATP Binding Cassette Transporter, Sub-Family B ; ATP Binding Cassette Transporter, Sub-Family G, Member 2 ; ATP-Binding Cassette Transporters - metabolism ; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism ; BCRP protein ; Biology ; Blotting, Western ; Breast cancer ; Cytochrome ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes therapy ; Diabetes, Gestational - metabolism ; DNA Primers - genetics ; DNA, Complementary - biosynthesis ; Drug dosages ; Drugs ; Efflux ; Enzymes ; Female ; Fetuses ; Gene expression ; Gene Expression Regulation - physiology ; Gestational diabetes ; Glucose ; Glycated Hemoglobin A - metabolism ; Glycosylated hemoglobin ; Hemoglobin ; HIV ; Hospitals ; Human immunodeficiency virus ; Humans ; Hyperglycemia ; Insulin ; Localization ; MDR1 protein ; Medicine ; Metabolism ; Metabolites ; Microbial drug resistance ; Multidrug resistance ; Multidrug Resistance-Associated Proteins - metabolism ; Neoplasm Proteins - metabolism ; Obstetrics ; Ontario ; P-Glycoprotein ; Patients ; Pharmaceutical sciences ; Pharmacology ; Pharmacy ; Placenta ; Placenta - metabolism ; Polymerase chain reaction ; Pregnancy ; Proteins ; Real-Time Polymerase Chain Reaction ; RNA ; Rodents ; Toxicology ; Tumors ; Type 1 diabetes ; Type 2 diabetes ; Western blotting ; Womens health ; Xenobiotics</subject><ispartof>PloS one, 2012-04, Vol.7 (4), p.e35027-e35027</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Anger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Anger et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4d0cead08eaeb9f57d2a359513e48e5614c10f0c0d8d43ead8912e16888ecc2a3</citedby><cites>FETCH-LOGICAL-c692t-4d0cead08eaeb9f57d2a359513e48e5614c10f0c0d8d43ead8912e16888ecc2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338746/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338746/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22558111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>van Veen, Hendrik W.</contributor><creatorcontrib>Anger, Gregory J</creatorcontrib><creatorcontrib>Cressman, Alex M</creatorcontrib><creatorcontrib>Piquette-Miller, Micheline</creatorcontrib><title>Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Drug efflux transporters in the placenta can significantly influence the materno-fetal transfer of a diverse array of drugs and other xenobiotics. To determine if clinically important drug efflux transporter expression is altered in pregnancies complicated by gestational diabetes mellitus (GDM-I) or type 1 diabetes mellitus (T1DM-I), we compared the expression of multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 2 (MRP2) and the breast cancer resistance protein (BCRP) via western blotting and quantitative real-time polymerase chain reaction in samples obtained from insulin-managed diabetic pregnancies to healthy term-matched controls. At the level of mRNA, we found significantly increased expression of MDR1 in the GDM-I group compared to both the T1DM-I (p<0.01) and control groups (p<0.05). Significant changes in the placental protein expression of MDR1, MRP2, and BCRP were not detected (p>0.05). Interestingly, there was a significant, positive correlation observed between plasma hemoglobin A1c levels (a retrospective marker of glycemic control) and both BCRP protein expression (r = 0.45, p<0.05) and BCRP mRNA expression (r = 0.58, p<0.01) in the insulin-managed DM groups. Collectively, the data suggest that the expression of placental efflux transporters is not altered in pregnancies complicated by diabetes when hyperglycemia is managed; however, given the relationship between BCRP expression and plasma hemoglobin A1c levels it is plausible that their expression could change in poorly managed diabetes.</description><subject>ABC transporters</subject><subject>Analysis of Variance</subject><subject>ATP Binding Cassette Transporter, Sub-Family B</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 2</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</subject><subject>BCRP protein</subject><subject>Biology</subject><subject>Blotting, Western</subject><subject>Breast cancer</subject><subject>Cytochrome</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes therapy</subject><subject>Diabetes, Gestational - metabolism</subject><subject>DNA Primers - genetics</subject><subject>DNA, Complementary - biosynthesis</subject><subject>Drug dosages</subject><subject>Drugs</subject><subject>Efflux</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fetuses</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - physiology</subject><subject>Gestational diabetes</subject><subject>Glucose</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Glycosylated hemoglobin</subject><subject>Hemoglobin</subject><subject>HIV</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Localization</subject><subject>MDR1 protein</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbial drug resistance</subject><subject>Multidrug resistance</subject><subject>Multidrug Resistance-Associated Proteins - metabolism</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Obstetrics</subject><subject>Ontario</subject><subject>P-Glycoprotein</subject><subject>Patients</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacology</subject><subject>Pharmacy</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Polymerase chain reaction</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA</subject><subject>Rodents</subject><subject>Toxicology</subject><subject>Tumors</subject><subject>Type 1 diabetes</subject><subject>Type 2 diabetes</subject><subject>Western blotting</subject><subject>Womens health</subject><subject>Xenobiotics</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-LEzEQxxdRvPP0PxBdEEQfWpNNdjf7ItRStXBw4K8HX0KazLYp2WQvyXr1vze1e0cr9yB5SJh85juZyUyWPcdoikmN323d4K0w095ZmCJESlTUD7Jz3JBiUhWIPDw6n2VPQtgiVBJWVY-zs6IoS4YxPs9-Lna9hxC0s7lr89mHeb5oWzPs8uiFDb3zEXzItc17IyTYKPLWuy6_cR3Y_EbHTboLg9F20gkr1qBypcUKIoSn2aNWmADPxv0i-_5x8W3-eXJ59Wk5n11OZNUUcUIVkiAUYiBg1bRlrQpByqbEBCiDssJUYtQiiRRTlCSSNbgAXDHGQMrEXmQvD7q9cYGPZQkck4KWDSoISsTyQCgntrz3uhP-N3dC878G59dc-KilAc6UUDWqikZSRQWVLOWimhajFFmUQJLW-zHasOpA7UvihTkRPb2xesPX7hcnhLCaVkngzSjg3fUAIfJOBwnGCAtuSO9G6WOaktR1Ql_9g96f3UitRUpA29aluHIvyme0rhGhGO3DTu-h0lLQaZl6qNXJfuLw9sQhMRF2cS2GEPjy65f_Z69-nLKvj9gNCBM3wZkhphYMpyA9gNK7EDy0d0XGiO9H4LYafD8CfByB5Pbi-IPunG57nvwBNfEBqQ</recordid><startdate>20120427</startdate><enddate>20120427</enddate><creator>Anger, Gregory J</creator><creator>Cressman, Alex M</creator><creator>Piquette-Miller, Micheline</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120427</creationdate><title>Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes</title><author>Anger, Gregory J ; Cressman, Alex M ; Piquette-Miller, Micheline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4d0cead08eaeb9f57d2a359513e48e5614c10f0c0d8d43ead8912e16888ecc2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>ABC transporters</topic><topic>Analysis of Variance</topic><topic>ATP Binding Cassette Transporter, Sub-Family B</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 2</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</topic><topic>BCRP protein</topic><topic>Biology</topic><topic>Blotting, Western</topic><topic>Breast cancer</topic><topic>Cytochrome</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes therapy</topic><topic>Diabetes, Gestational - metabolism</topic><topic>DNA Primers - genetics</topic><topic>DNA, Complementary - biosynthesis</topic><topic>Drug dosages</topic><topic>Drugs</topic><topic>Efflux</topic><topic>Enzymes</topic><topic>Female</topic><topic>Fetuses</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - physiology</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Glycosylated hemoglobin</topic><topic>Hemoglobin</topic><topic>HIV</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Localization</topic><topic>MDR1 protein</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microbial drug resistance</topic><topic>Multidrug resistance</topic><topic>Multidrug Resistance-Associated Proteins - metabolism</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Obstetrics</topic><topic>Ontario</topic><topic>P-Glycoprotein</topic><topic>Patients</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacology</topic><topic>Pharmacy</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Polymerase chain reaction</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA</topic><topic>Rodents</topic><topic>Toxicology</topic><topic>Tumors</topic><topic>Type 1 diabetes</topic><topic>Type 2 diabetes</topic><topic>Western blotting</topic><topic>Womens health</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anger, Gregory J</creatorcontrib><creatorcontrib>Cressman, Alex M</creatorcontrib><creatorcontrib>Piquette-Miller, Micheline</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anger, Gregory J</au><au>Cressman, Alex M</au><au>Piquette-Miller, Micheline</au><au>van Veen, Hendrik W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-04-27</date><risdate>2012</risdate><volume>7</volume><issue>4</issue><spage>e35027</spage><epage>e35027</epage><pages>e35027-e35027</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Drug efflux transporters in the placenta can significantly influence the materno-fetal transfer of a diverse array of drugs and other xenobiotics. To determine if clinically important drug efflux transporter expression is altered in pregnancies complicated by gestational diabetes mellitus (GDM-I) or type 1 diabetes mellitus (T1DM-I), we compared the expression of multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 2 (MRP2) and the breast cancer resistance protein (BCRP) via western blotting and quantitative real-time polymerase chain reaction in samples obtained from insulin-managed diabetic pregnancies to healthy term-matched controls. At the level of mRNA, we found significantly increased expression of MDR1 in the GDM-I group compared to both the T1DM-I (p<0.01) and control groups (p<0.05). Significant changes in the placental protein expression of MDR1, MRP2, and BCRP were not detected (p>0.05). Interestingly, there was a significant, positive correlation observed between plasma hemoglobin A1c levels (a retrospective marker of glycemic control) and both BCRP protein expression (r = 0.45, p<0.05) and BCRP mRNA expression (r = 0.58, p<0.01) in the insulin-managed DM groups. Collectively, the data suggest that the expression of placental efflux transporters is not altered in pregnancies complicated by diabetes when hyperglycemia is managed; however, given the relationship between BCRP expression and plasma hemoglobin A1c levels it is plausible that their expression could change in poorly managed diabetes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22558111</pmid><doi>10.1371/journal.pone.0035027</doi><tpages>e35027</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-04, Vol.7 (4), p.e35027-e35027 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1324590230 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | ABC transporters Analysis of Variance ATP Binding Cassette Transporter, Sub-Family B ATP Binding Cassette Transporter, Sub-Family G, Member 2 ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism BCRP protein Biology Blotting, Western Breast cancer Cytochrome Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - metabolism Diabetes therapy Diabetes, Gestational - metabolism DNA Primers - genetics DNA, Complementary - biosynthesis Drug dosages Drugs Efflux Enzymes Female Fetuses Gene expression Gene Expression Regulation - physiology Gestational diabetes Glucose Glycated Hemoglobin A - metabolism Glycosylated hemoglobin Hemoglobin HIV Hospitals Human immunodeficiency virus Humans Hyperglycemia Insulin Localization MDR1 protein Medicine Metabolism Metabolites Microbial drug resistance Multidrug resistance Multidrug Resistance-Associated Proteins - metabolism Neoplasm Proteins - metabolism Obstetrics Ontario P-Glycoprotein Patients Pharmaceutical sciences Pharmacology Pharmacy Placenta Placenta - metabolism Polymerase chain reaction Pregnancy Proteins Real-Time Polymerase Chain Reaction RNA Rodents Toxicology Tumors Type 1 diabetes Type 2 diabetes Western blotting Womens health Xenobiotics |
| title | Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T02%3A25%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20ABC%20Efflux%20transporters%20in%20placenta%20from%20women%20with%20insulin-managed%20diabetes&rft.jtitle=PloS%20one&rft.au=Anger,%20Gregory%20J&rft.date=2012-04-27&rft.volume=7&rft.issue=4&rft.spage=e35027&rft.epage=e35027&rft.pages=e35027-e35027&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0035027&rft_dat=%3Cgale_plos_%3EA477034106%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1324590230&rft_id=info:pmid/22558111&rft_galeid=A477034106&rft_doaj_id=oai_doaj_org_article_8dad70629c4d4a4c8abed9f103eaa5e3&rfr_iscdi=true |