Myosin light chain kinase mediates intestinal barrier disruption following burn injury

Severe burn injury results in the loss of intestinal barrier function, however, the underlying mechanism remains unclear. Myosin light chain (MLC) phosphorylation mediated by MLC kinase (MLCK) is critical to the pathophysiological regulation of intestinal barrier function. We hypothesized that the M...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e34946-e34946
Hauptverfasser:	Chen, Chuanli, Wang, Pei, Su, Qin, Wang, Shiliang, Wang, Fengjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Azepines - pharmacology Biology Burns Burns - enzymology Burns - pathology Chains Cytokines Dextran Dextrans Disease Models, Animal Disruption Enzyme Inhibitors - pharmacology Extracellular matrix Fluorescein Fluorescein isothiocyanate Heat shock proteins Hospitals Injuries Intestinal Mucosa - enzymology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Kinases Laboratories Male Medical research Medicine Mice Mice, Inbred BALB C Mucosa Muscle proteins Myosin Myosin Light Chains - metabolism Myosin-light-chain kinase Myosin-Light-Chain Kinase - antagonists & inhibitors Myosin-Light-Chain Kinase - metabolism Permeability Permeability - drug effects Phosphorylation Phosphorylation - drug effects Proteins Rodents Small intestine Sodium Studies Tight Junctions - drug effects Tight Junctions - metabolism Tight Junctions - pathology Trauma Zonula occludens-1 protein Zonula Occludens-1 Protein - metabolism
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