1,2-Octanediol, a novel surfactant, for treating head louse infestation: identification of activity, formulation, and randomised, controlled trials
Interest in developing physically active pediculicides has identified new active substances. The objective was to evaluate a new treatment for clinical efficacy. We describe the selection of 1,2-octanediol as a potential pediculicide. Clinical studies were community based. The main outcome measure w...
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| Veröffentlicht in: | PloS one 2012-04, Vol.7 (4), p.e35419 |
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| creator | Burgess, Ian F Lee, Peter N Kay, Katrina Jones, Ruth Brunton, Elizabeth R |
| description | Interest in developing physically active pediculicides has identified new active substances. The objective was to evaluate a new treatment for clinical efficacy.
We describe the selection of 1,2-octanediol as a potential pediculicide. Clinical studies were community based. The main outcome measure was no live lice, after two treatments, with follow up visits over 14 days. Study 1 was a proof of concept with 18/20 (90%) participants cured. Study 2 was a multicentre, parallel, randomised, observer-blind study (520 participants) that compared 0.5% malathion liquid with 1,2-octanediol lotion (20% alcohol) applied 2-2.5 hours or 8 hours/overnight. 1,2-octanediol lotion was significantly (p |
| doi_str_mv | 10.1371/journal.pone.0035419 |
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We describe the selection of 1,2-octanediol as a potential pediculicide. Clinical studies were community based. The main outcome measure was no live lice, after two treatments, with follow up visits over 14 days. Study 1 was a proof of concept with 18/20 (90%) participants cured. Study 2 was a multicentre, parallel, randomised, observer-blind study (520 participants) that compared 0.5% malathion liquid with 1,2-octanediol lotion (20% alcohol) applied 2-2.5 hours or 8 hours/overnight. 1,2-octanediol lotion was significantly (p<0.0005) more effective with success for 124/175 (70.9%) RR = 1.50 (97.5% CI, 1.22 to 1.85) for 2-2.5 hours, and 153/174 (87.9%) RR = 1.86 (97.5% CI, 1.54 to 2.26) for 8 hours/overnight compared with 81/171 (47.4%) for malathion. Study 3, a two centre, parallel, randomised, observer-blind study (121 participants), compared 1,2-octanediol lotion, 2-2.5 hours with 1,2-octanediol alcohol free mousse applied for 2-2.5 hours or 8 hours/overnight. The mousse applied for 8 hours/overnight cured 31/40 (77.5%), compared with 24/40 (60.0%) for lotion (RR = 1.29, 95% CI, 0.95 to 1.75; NNT = 5.7) but mousse applied for 2-2.5 hours 17/41 (41.5%) was less effective than lotion (RR = 0.69, 95% CI, 0.44 to 1.08). Adverse events were more common using 1,2-octanediol lotion at both 2-2.5 hours (12.0%, p = 0.001) and 8 hours/overnight (14.9%, p<0.0005), compared with 0.5% malathion (2.3%). Similar reactions were more frequent (p<0.045) using lotion compared with mousse.
1,2-octanediol was found to eliminate head louse infestation. It is believed to disrupt the insect's cuticular lipid, resulting in dehydration. The alcohol free mousse is more acceptable exhibiting significantly fewer adverse reactions.
Controlled-Trials.com ISRCTN66611560, ISRCTN91870666, ISRCTN28722846.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0035419</identifier><identifier>PMID: 22523593</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Active control ; Adolescent ; Adult ; Alcohol ; Alcohol free ; Alcohols ; Animals ; Biology ; Chemistry ; Child ; Child, Preschool ; Clinical trials ; Dehydration ; Ethics ; Fatty acids ; Female ; Humans ; Hydrocarbons ; Infestation ; Insecticides ; Insects ; International conferences ; Laboratories ; Lice ; Lice Infestations - drug therapy ; Lipids ; Liposcelis bostrychophila ; Malathion ; Male ; Medical research ; Medicine ; Octanols - administration & dosage ; Octanols - adverse effects ; Octanols - therapeutic use ; Pediculidae ; Pediculus ; Pediculus humanus ; R&D ; Randomization ; Research & development ; Studies ; Surface active agents ; Surface-Active Agents - adverse effects ; Surface-Active Agents - therapeutic use</subject><ispartof>PloS one, 2012-04, Vol.7 (4), p.e35419</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Burgess et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Burgess et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ecd4cc0c8613d74166e147c1a8dd1805d8b7ed0a23e61d56e49bb05608e224f13</citedby><cites>FETCH-LOGICAL-c692t-ecd4cc0c8613d74166e147c1a8dd1805d8b7ed0a23e61d56e49bb05608e224f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327678/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327678/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23870,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22523593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sinnis, Photini</contributor><creatorcontrib>Burgess, Ian F</creatorcontrib><creatorcontrib>Lee, Peter N</creatorcontrib><creatorcontrib>Kay, Katrina</creatorcontrib><creatorcontrib>Jones, Ruth</creatorcontrib><creatorcontrib>Brunton, Elizabeth R</creatorcontrib><title>1,2-Octanediol, a novel surfactant, for treating head louse infestation: identification of activity, formulation, and randomised, controlled trials</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Interest in developing physically active pediculicides has identified new active substances. The objective was to evaluate a new treatment for clinical efficacy.
We describe the selection of 1,2-octanediol as a potential pediculicide. Clinical studies were community based. The main outcome measure was no live lice, after two treatments, with follow up visits over 14 days. Study 1 was a proof of concept with 18/20 (90%) participants cured. Study 2 was a multicentre, parallel, randomised, observer-blind study (520 participants) that compared 0.5% malathion liquid with 1,2-octanediol lotion (20% alcohol) applied 2-2.5 hours or 8 hours/overnight. 1,2-octanediol lotion was significantly (p<0.0005) more effective with success for 124/175 (70.9%) RR = 1.50 (97.5% CI, 1.22 to 1.85) for 2-2.5 hours, and 153/174 (87.9%) RR = 1.86 (97.5% CI, 1.54 to 2.26) for 8 hours/overnight compared with 81/171 (47.4%) for malathion. Study 3, a two centre, parallel, randomised, observer-blind study (121 participants), compared 1,2-octanediol lotion, 2-2.5 hours with 1,2-octanediol alcohol free mousse applied for 2-2.5 hours or 8 hours/overnight. The mousse applied for 8 hours/overnight cured 31/40 (77.5%), compared with 24/40 (60.0%) for lotion (RR = 1.29, 95% CI, 0.95 to 1.75; NNT = 5.7) but mousse applied for 2-2.5 hours 17/41 (41.5%) was less effective than lotion (RR = 0.69, 95% CI, 0.44 to 1.08). Adverse events were more common using 1,2-octanediol lotion at both 2-2.5 hours (12.0%, p = 0.001) and 8 hours/overnight (14.9%, p<0.0005), compared with 0.5% malathion (2.3%). Similar reactions were more frequent (p<0.045) using lotion compared with mousse.
1,2-octanediol was found to eliminate head louse infestation. It is believed to disrupt the insect's cuticular lipid, resulting in dehydration. The alcohol free mousse is more acceptable exhibiting significantly fewer adverse reactions.
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administration & dosage</subject><subject>Octanols - adverse effects</subject><subject>Octanols - therapeutic use</subject><subject>Pediculidae</subject><subject>Pediculus</subject><subject>Pediculus humanus</subject><subject>R&D</subject><subject>Randomization</subject><subject>Research & development</subject><subject>Studies</subject><subject>Surface active agents</subject><subject>Surface-Active Agents - adverse effects</subject><subject>Surface-Active Agents - therapeutic use</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNU2uLEzEUHURx1-o_EA0IgtDWPGaSGT8Iy-KjsFDw9TWkyZ02JZ3UZKa4v8M_bKadXTqgIIE8bs45N5ybm2XPCZ4TJsjbre9Co9x87xuYY8yKnFQPsktSMTrjFLOHZ_uL7EmMW4wLVnL-OLugtKCsqNhl9ptM6WypW9WAsd5NkUKNP4BDsQu16uPtFNU-oDaAam2zRhtQBjnfRUC2qSG2Keybd8gaaFpbW308I1-jRLcH294eBXadO16kDI1BIU1-ZyOYKdK-aYN3DkxKYpWLT7NHdVrg2bBOsu8fP3y7_jy7WX5aXF_dzDSvaDsDbXKtsS45YUbkhHMgudBElcaQEhemXAkwWFEGnJiCQ16tVrjguARK85qwSfbypLt3PsrBzygJo3khWPIuIRYnhPFqK_fB7lS4lV5ZeQz4sJYqtFY7kAorRqBcVdzUuVhVShBeFYwJKpRiyflJ9n7I1q12YHRyKyg3Eh3fNHYj1_4gGaOCizIJvBoEgv_ZJeP_8eQBtVbpValCPonpZLWWV7kQuKQ57rXmf0GlYWBnU0Ggtik-IrwZEfqiwa92rboY5eLrl__HLn-Msa_PsOlvuXYTvev6rxLHwPwE1MHHGKC-d45g2TfEnRuybwg5NESivTh3_Z501wHsDwOtB4E</recordid><startdate>20120416</startdate><enddate>20120416</enddate><creator>Burgess, Ian F</creator><creator>Lee, Peter N</creator><creator>Kay, Katrina</creator><creator>Jones, Ruth</creator><creator>Brunton, Elizabeth R</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120416</creationdate><title>1,2-Octanediol, a novel surfactant, for treating head louse infestation: identification of activity, formulation, and randomised, controlled trials</title><author>Burgess, Ian F ; Lee, Peter N ; Kay, Katrina ; Jones, Ruth ; Brunton, Elizabeth R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ecd4cc0c8613d74166e147c1a8dd1805d8b7ed0a23e61d56e49bb05608e224f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Active control</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Alcohol</topic><topic>Alcohol free</topic><topic>Alcohols</topic><topic>Animals</topic><topic>Biology</topic><topic>Chemistry</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical trials</topic><topic>Dehydration</topic><topic>Ethics</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocarbons</topic><topic>Infestation</topic><topic>Insecticides</topic><topic>Insects</topic><topic>International conferences</topic><topic>Laboratories</topic><topic>Lice</topic><topic>Lice Infestations - 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The objective was to evaluate a new treatment for clinical efficacy.
We describe the selection of 1,2-octanediol as a potential pediculicide. Clinical studies were community based. The main outcome measure was no live lice, after two treatments, with follow up visits over 14 days. Study 1 was a proof of concept with 18/20 (90%) participants cured. Study 2 was a multicentre, parallel, randomised, observer-blind study (520 participants) that compared 0.5% malathion liquid with 1,2-octanediol lotion (20% alcohol) applied 2-2.5 hours or 8 hours/overnight. 1,2-octanediol lotion was significantly (p<0.0005) more effective with success for 124/175 (70.9%) RR = 1.50 (97.5% CI, 1.22 to 1.85) for 2-2.5 hours, and 153/174 (87.9%) RR = 1.86 (97.5% CI, 1.54 to 2.26) for 8 hours/overnight compared with 81/171 (47.4%) for malathion. Study 3, a two centre, parallel, randomised, observer-blind study (121 participants), compared 1,2-octanediol lotion, 2-2.5 hours with 1,2-octanediol alcohol free mousse applied for 2-2.5 hours or 8 hours/overnight. The mousse applied for 8 hours/overnight cured 31/40 (77.5%), compared with 24/40 (60.0%) for lotion (RR = 1.29, 95% CI, 0.95 to 1.75; NNT = 5.7) but mousse applied for 2-2.5 hours 17/41 (41.5%) was less effective than lotion (RR = 0.69, 95% CI, 0.44 to 1.08). Adverse events were more common using 1,2-octanediol lotion at both 2-2.5 hours (12.0%, p = 0.001) and 8 hours/overnight (14.9%, p<0.0005), compared with 0.5% malathion (2.3%). Similar reactions were more frequent (p<0.045) using lotion compared with mousse.
1,2-octanediol was found to eliminate head louse infestation. It is believed to disrupt the insect's cuticular lipid, resulting in dehydration. The alcohol free mousse is more acceptable exhibiting significantly fewer adverse reactions.
Controlled-Trials.com ISRCTN66611560, ISRCTN91870666, ISRCTN28722846.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22523593</pmid><doi>10.1371/journal.pone.0035419</doi><tpages>e35419</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2012-04, Vol.7 (4), p.e35419 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Active control Adolescent Adult Alcohol Alcohol free Alcohols Animals Biology Chemistry Child Child, Preschool Clinical trials Dehydration Ethics Fatty acids Female Humans Hydrocarbons Infestation Insecticides Insects International conferences Laboratories Lice Lice Infestations - drug therapy Lipids Liposcelis bostrychophila Malathion Male Medical research Medicine Octanols - administration & dosage Octanols - adverse effects Octanols - therapeutic use Pediculidae Pediculus Pediculus humanus R&D Randomization Research & development Studies Surface active agents Surface-Active Agents - adverse effects Surface-Active Agents - therapeutic use |
| title | 1,2-Octanediol, a novel surfactant, for treating head louse infestation: identification of activity, formulation, and randomised, controlled trials |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T03%3A11%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=1,2-Octanediol,%20a%20novel%20surfactant,%20for%20treating%20head%20louse%20infestation:%20identification%20of%20activity,%20formulation,%20and%20randomised,%20controlled%20trials&rft.jtitle=PloS%20one&rft.au=Burgess,%20Ian%20F&rft.date=2012-04-16&rft.volume=7&rft.issue=4&rft.spage=e35419&rft.pages=e35419-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0035419&rft_dat=%3Cgale_plos_%3EA477082408%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1324573932&rft_id=info:pmid/22523593&rft_galeid=A477082408&rft_doaj_id=oai_doaj_org_article_a0a31e8b96df47b9a7169533727aa305&rfr_iscdi=true |