The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica
Puumala hantavirus (PUUV) infection, also known as nephropathia epidemica, is the most common cause of hemorrhagic fever with renal syndrome (HFRS) in Europe. The pathogenesis of PUUV nephropathia epidemica is complex and multifactorial, and the risk factors for severe acute kidney injury (AKI) duri...
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| description | Puumala hantavirus (PUUV) infection, also known as nephropathia epidemica, is the most common cause of hemorrhagic fever with renal syndrome (HFRS) in Europe. The pathogenesis of PUUV nephropathia epidemica is complex and multifactorial, and the risk factors for severe acute kidney injury (AKI) during acute PUUV infection are not well defined. We conducted a prospective study of hospitalized patients with PUUV infection in Tampere, Finland to identify acute illness risk factors for HFRS severity. Serial daily blood and urine samples were collected throughout acute illness and at 2 week and 6 month convalescent visits. By univariate analyses, the maximum white blood cell count during acute illness was a risk factor for severe AKI. There were no significant associations between PUUV-induced AKI severity and platelet counts, C-reactive protein, or alanine aminotransferase levels. Maximum plasma interleukin (IL)-6, urine IL-6, and urine IL-8 concentrations were positively associated with PUUV-induced AKI. Finally, the maximum urinary sediment GATA-3 mRNA level was positively correlated with the peak fold-change in serum creatinine, regardless of AKI severity classification. By multivariate analyses, we found that the maximum levels of leukocytes and urinary sediment GATA-3 mRNA during acute illness were independent risk factors for severe PUUV-induced AKI. We have identified novel acute illness risk factors for severe PUUV-induced AKI. |
| doi_str_mv | 10.1371/journal.pone.0035402 |
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The pathogenesis of PUUV nephropathia epidemica is complex and multifactorial, and the risk factors for severe acute kidney injury (AKI) during acute PUUV infection are not well defined. We conducted a prospective study of hospitalized patients with PUUV infection in Tampere, Finland to identify acute illness risk factors for HFRS severity. Serial daily blood and urine samples were collected throughout acute illness and at 2 week and 6 month convalescent visits. By univariate analyses, the maximum white blood cell count during acute illness was a risk factor for severe AKI. There were no significant associations between PUUV-induced AKI severity and platelet counts, C-reactive protein, or alanine aminotransferase levels. Maximum plasma interleukin (IL)-6, urine IL-6, and urine IL-8 concentrations were positively associated with PUUV-induced AKI. Finally, the maximum urinary sediment GATA-3 mRNA level was positively correlated with the peak fold-change in serum creatinine, regardless of AKI severity classification. By multivariate analyses, we found that the maximum levels of leukocytes and urinary sediment GATA-3 mRNA during acute illness were independent risk factors for severe PUUV-induced AKI. We have identified novel acute illness risk factors for severe PUUV-induced AKI.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0035402</identifier><identifier>PMID: 22523590</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute Kidney Injury - etiology ; Adult ; Alanine ; Alanine transaminase ; Blood ; C-reactive protein ; Creatinine ; Creatinine - blood ; Cytokines ; Epidemics ; Female ; Fever ; Finland ; GATA-3 protein ; GATA3 Transcription Factor - urine ; Gene expression ; Hantavirus ; Health aspects ; Health risks ; Hemodialysis ; Hemorrhage ; Hemorrhagic fever with renal syndrome ; Hemorrhagic Fever with Renal Syndrome - complications ; Hemorrhagic Fever with Renal Syndrome - pathology ; Hemorrhagic Fever with Renal Syndrome - urine ; Hemorrhagic fevers ; Hospital patients ; Hospitalization ; Hospitals ; Humans ; Illnesses ; Infections ; Interleukin 6 ; Interleukin 8 ; Interleukin-6 - blood ; Interleukin-6 - urine ; Interleukin-8 - urine ; Interleukins ; Kidneys ; Laboratories ; Length of Stay ; Leukocytes ; Leukocytosis ; Male ; Medical research ; Medical schools ; Medicine ; Messenger RNA ; Middle Aged ; mRNA ; Pathogenesis ; Plasma ; Prospective Studies ; Puumala virus ; Rheumatology ; Risk analysis ; Risk Factors ; RNA, Messenger - urine ; Sediments ; Studies ; Transcription factors ; Urine ; Viruses ; White blood cell count</subject><ispartof>PloS one, 2012-04, Vol.7 (4), p.e35402-e35402</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Libraty et al. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Libraty et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-1a5035aa81f4d3533f6d5a30677763e09d7b0cc9f8ca600ff3103cd2b873506c3</citedby><cites>FETCH-LOGICAL-c585t-1a5035aa81f4d3533f6d5a30677763e09d7b0cc9f8ca600ff3103cd2b873506c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327672/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327672/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22523590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Libraty, Daniel H</creatorcontrib><creatorcontrib>Mäkelä, Satu</creatorcontrib><creatorcontrib>Vlk, Jennifer</creatorcontrib><creatorcontrib>Hurme, Mikko</creatorcontrib><creatorcontrib>Vaheri, Antti</creatorcontrib><creatorcontrib>Ennis, Francis A</creatorcontrib><creatorcontrib>Mustonen, Jukka</creatorcontrib><title>The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Puumala hantavirus (PUUV) infection, also known as nephropathia epidemica, is the most common cause of hemorrhagic fever with renal syndrome (HFRS) in Europe. The pathogenesis of PUUV nephropathia epidemica is complex and multifactorial, and the risk factors for severe acute kidney injury (AKI) during acute PUUV infection are not well defined. We conducted a prospective study of hospitalized patients with PUUV infection in Tampere, Finland to identify acute illness risk factors for HFRS severity. Serial daily blood and urine samples were collected throughout acute illness and at 2 week and 6 month convalescent visits. By univariate analyses, the maximum white blood cell count during acute illness was a risk factor for severe AKI. There were no significant associations between PUUV-induced AKI severity and platelet counts, C-reactive protein, or alanine aminotransferase levels. Maximum plasma interleukin (IL)-6, urine IL-6, and urine IL-8 concentrations were positively associated with PUUV-induced AKI. Finally, the maximum urinary sediment GATA-3 mRNA level was positively correlated with the peak fold-change in serum creatinine, regardless of AKI severity classification. By multivariate analyses, we found that the maximum levels of leukocytes and urinary sediment GATA-3 mRNA during acute illness were independent risk factors for severe PUUV-induced AKI. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Libraty, Daniel H</au><au>Mäkelä, Satu</au><au>Vlk, Jennifer</au><au>Hurme, Mikko</au><au>Vaheri, Antti</au><au>Ennis, Francis A</au><au>Mustonen, Jukka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-04-16</date><risdate>2012</risdate><volume>7</volume><issue>4</issue><spage>e35402</spage><epage>e35402</epage><pages>e35402-e35402</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Puumala hantavirus (PUUV) infection, also known as nephropathia epidemica, is the most common cause of hemorrhagic fever with renal syndrome (HFRS) in Europe. The pathogenesis of PUUV nephropathia epidemica is complex and multifactorial, and the risk factors for severe acute kidney injury (AKI) during acute PUUV infection are not well defined. We conducted a prospective study of hospitalized patients with PUUV infection in Tampere, Finland to identify acute illness risk factors for HFRS severity. Serial daily blood and urine samples were collected throughout acute illness and at 2 week and 6 month convalescent visits. By univariate analyses, the maximum white blood cell count during acute illness was a risk factor for severe AKI. There were no significant associations between PUUV-induced AKI severity and platelet counts, C-reactive protein, or alanine aminotransferase levels. Maximum plasma interleukin (IL)-6, urine IL-6, and urine IL-8 concentrations were positively associated with PUUV-induced AKI. Finally, the maximum urinary sediment GATA-3 mRNA level was positively correlated with the peak fold-change in serum creatinine, regardless of AKI severity classification. By multivariate analyses, we found that the maximum levels of leukocytes and urinary sediment GATA-3 mRNA during acute illness were independent risk factors for severe PUUV-induced AKI. We have identified novel acute illness risk factors for severe PUUV-induced AKI.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22523590</pmid><doi>10.1371/journal.pone.0035402</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-04, Vol.7 (4), p.e35402-e35402 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acute Kidney Injury - etiology Adult Alanine Alanine transaminase Blood C-reactive protein Creatinine Creatinine - blood Cytokines Epidemics Female Fever Finland GATA-3 protein GATA3 Transcription Factor - urine Gene expression Hantavirus Health aspects Health risks Hemodialysis Hemorrhage Hemorrhagic fever with renal syndrome Hemorrhagic Fever with Renal Syndrome - complications Hemorrhagic Fever with Renal Syndrome - pathology Hemorrhagic Fever with Renal Syndrome - urine Hemorrhagic fevers Hospital patients Hospitalization Hospitals Humans Illnesses Infections Interleukin 6 Interleukin 8 Interleukin-6 - blood Interleukin-6 - urine Interleukin-8 - urine Interleukins Kidneys Laboratories Length of Stay Leukocytes Leukocytosis Male Medical research Medical schools Medicine Messenger RNA Middle Aged mRNA Pathogenesis Plasma Prospective Studies Puumala virus Rheumatology Risk analysis Risk Factors RNA, Messenger - urine Sediments Studies Transcription factors Urine Viruses White blood cell count |
| title | The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T21%3A15%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20degree%20of%20leukocytosis%20and%20urine%20GATA-3%20mRNA%20levels%20are%20risk%20factors%20for%20severe%20acute%20kidney%20injury%20in%20Puumala%20virus%20nephropathia%20epidemica&rft.jtitle=PloS%20one&rft.au=Libraty,%20Daniel%20H&rft.date=2012-04-16&rft.volume=7&rft.issue=4&rft.spage=e35402&rft.epage=e35402&rft.pages=e35402-e35402&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0035402&rft_dat=%3Cgale_plos_%3EA477082379%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1324573930&rft_id=info:pmid/22523590&rft_galeid=A477082379&rft_doaj_id=oai_doaj_org_article_784a32aab4174218a7d8d531e9018d5d&rfr_iscdi=true |