Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice

This study sought to test whether targeted overexpression of osteoactivin (OA) in cells of osteoclastic lineage, using the tartrate-resistant acid phosphase (TRAP) exon 1B/C promoter to drive OA expression, would increase bone resorption and bone loss in vivo. OA transgenic osteoclasts showed ∼2-fol...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35280-e35280
Hauptverfasser:	Sheng, Matilda H-C, Wergedal, Jon E, Mohan, Subburaman, Amoui, Mehran, Baylink, David J, Lau, K-H William
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase (tartrate-resistant) Acid Phosphatase - genetics Acid Phosphatase - metabolism Acid resistance Age Factors Animals Antigens Biocompatibility Biology Biomarkers Biomedical materials Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone and Bones - pathology Bone Density Bone growth Bone histomorphometry Bone loss Bone matrix Bone resorption Bone Resorption - blood Bone Resorption - genetics Bone Resorption - metabolism Cell Nucleus Size Cell Size Collagen (type I) Comparative analysis Computed tomography Eye Proteins - biosynthesis Eye Proteins - genetics Female Gelatinase B Gender differences Gene Expression Genetic engineering Growth factors In vivo methods and tests Isoenzymes - genetics Isoenzymes - metabolism Kidney diseases Kinases Male Medicine Melanoma Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Mice Mice, Inbred C57BL Mice, Transgenic Musculoskeletal system Osteoblasts Osteoblasts - metabolism Osteocalcin Osteocalcin - blood Osteoclasts Osteoclasts - metabolism Osteogenesis Peptide Fragments - blood Phenotype Phosphatase Plasma levels Procollagen - blood Promoter Regions, Genetic Proteins RNA Rodents siRNA src-Family Kinases - metabolism Tartrate-Resistant Acid Phosphatase Transgenic animals Transgenic mice X-Ray Microtomography Young adults
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