Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway

Cytochrome P450 2A6 (CYP2A6) is known to metabolize nicotine, the major constituent of tobacco, leading to the production of toxic metabolites and induction of oxidative stress that result in liver damage and lung cancer. Recently, we have shown that CYP2A6 is induced by ethanol and metabolizes nico...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35505
Hauptverfasser:	Jin, Mengyao, Kumar, Anil, Kumar, Santosh
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Alcohol Alcoholic beverages Antioxidants Arthritis Aryl Hydrocarbon Hydroxylases - metabolism Ascorbic acid Ascorbic Acid - pharmacology BHA Biology Blood-brain barrier Butylated hydroxyanisole Cigarettes Cotinine Cytochrome Cytochrome P-450 Cytochrome P-450 CYP2A6 Cytochrome P-450 CYP2E1 - metabolism Cytochrome P450 Energy law Enzyme Activation - drug effects Enzymes Ethanol Ethanol - metabolism Ethanol - pharmacology Gene expression Growth factors HIV Human immunodeficiency virus Humans Infections Inhibitors Liver Liver cancer Liver diseases Lung cancer Lung diseases MAP kinase Medicine Metabolism Metabolites Mitogen-Activated Protein Kinase Kinases - metabolism Models, Biological Monocytes Monocytes - drug effects Monocytes - enzymology Monocytes - metabolism NF-E2-Related Factor 2 - metabolism Nicotine Nuclei Oxidative stress Oxidative Stress - drug effects Oxygen Pharmacology Pharmacy Phosphorylation Protein kinase C Protein Kinase C - metabolism Protein kinases Proteins Reactive oxygen species RNA Rodents Signal Transduction - drug effects Smoking Staurosporine Sulfide Sulfides Tobacco Toxicology Translocation U937 Cells Vitamin C
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