Protective immunity to Listeria monocytogenes infection mediated by recombinant Listeria innocua harboring the VGC locus

In this study we propose a novel bacterial vaccine strategy where non-pathogenic bacteria are complemented with traits desirable for the induction of protective immunity. To illustrate the proof of principle of this novel vaccination strategy, we use the model organism of intracellular immunity List...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35503-e35503
Hauptverfasser:	Mohamed, Walid, Sethi, Shneh, Tchatalbachev, Svetlin, Darji, Ayub, Chakraborty, Trinad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Bacteria Bacterial artificial chromosomes Bacterial infections Bacterial Load Bacterial Vaccines - immunology Biological response modifiers Biology CD8 antigen Cell-mediated immunity Cells, Cultured Copy number Cytokines - blood Female Genomics Hypersensitivity, Delayed - microbiology Immunity Immunity, Cellular Infections Inflammation Inflammatory response Interferon Interferons - metabolism L-Selectin - metabolism Listeria Listeria innocua Listeria monocytogenes Listeria monocytogenes - genetics Listeria monocytogenes - immunology Listeriosis - immunology Listeriosis - microbiology Listeriosis - prevention & control Liver Lymphocytes Lymphocytes T Medical research Medicine Mice Mice, Inbred BALB C Mice, Inbred C57BL Multigene Family Proteins Spleen Spleen - immunology Spleen - microbiology Spleen - pathology T cells T-Lymphocytes - immunology Vaccination Vaccination - methods Vaccines Vaccines, Attenuated - immunology Vaccines, Synthetic - immunology Vectors Virulence Virulence (Microbiology) Virulence Factors - genetics
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