Morphological and pathological evolution of the brain microcirculation in aging and Alzheimer's disease

Key pathological hallmarks of Alzheimer's disease (AD), including amyloid plaques, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles do not completely account for cognitive impairment, therefore other factors such as cardiovascular and cerebrovascular pathologies, may contribute to...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e36893-e36893
Hauptverfasser:	Hunter, Jesse M, Kwan, Jason, Malek-Ahmadi, Michael, Maarouf, Chera L, Kokjohn, Tyler A, Belden, Christine, Sabbagh, Marwan N, Beach, Thomas G, Roher, Alex E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Advertising executives Age Aged Aged, 80 and over Aging Aging - metabolism Aging - pathology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Angiogenesis Apolipoprotein E4 - metabolism Apolipoproteins Biochemistry Biology Biomarkers Brain Brain - blood supply Brain research Capillaries Capillaries - metabolism Capillaries - pathology Cardiovascular disease Carriers Cerebral amyloid angiopathy Cerebral Cortex - metabolism Cerebral Cortex - pathology Cerebrovascular system Cholinergic Neurons - metabolism Cholinergic Neurons - pathology Cognitive ability Cohort Studies Consortia Cortex Dementia Dementia - metabolism Dementia - pathology Dementia disorders Ethnicity Evolution Female Humans Hydroxylase Immunohistochemistry Immunohistochemistry - methods Immunotherapy Innervation Macular degeneration Male Medical imaging Medical research Medicine Microcirculation Microvasculature Microvessels - metabolism Microvessels - pathology Morphology Neurodegenerative diseases Neurofibrillary tangles Neurons, Afferent - metabolism Neurons, Afferent - pathology Neuropathology Norepinephrine Pathogenesis Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Review boards Rodents Senile plaques Staining Structural integrity Substantia grisea Tyrosine Tyrosine 3-monooxygenase Tyrosine 3-Monooxygenase - metabolism Vasoconstriction Vasoconstriction - physiology Vasodilation Vasodilation - physiology Vesicular Acetylcholine Transport Proteins - metabolism Vesicular acetylcholine transporter
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