Mechanics regulates fate decisions of human embryonic stem cells
Research on human embryonic stem cells (hESCs) has attracted much attention given their great potential for tissue regenerative therapy and fundamental developmental biology studies. Yet, there is still limited understanding of how mechanical signals in the local cellular microenvironment of hESCs r...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-05, Vol.7 (5), p.e37178-e37178 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e37178 |
|---|---|
| container_issue | 5 |
| container_start_page | e37178 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Sun, Yubing Villa-Diaz, Luis G Lam, Raymond H W Chen, Weiqiang Krebsbach, Paul H Fu, Jianping |
| description | Research on human embryonic stem cells (hESCs) has attracted much attention given their great potential for tissue regenerative therapy and fundamental developmental biology studies. Yet, there is still limited understanding of how mechanical signals in the local cellular microenvironment of hESCs regulate their fate decisions. Here, we applied a microfabricated micromechanical platform to investigate the mechanoresponsive behaviors of hESCs. We demonstrated that hESCs are mechanosensitive, and they could increase their cytoskeleton contractility with matrix rigidity. Furthermore, rigid substrates supported maintenance of pluripotency of hESCs. Matrix mechanics-mediated cytoskeleton contractility might be functionally correlated with E-cadherin expressions in cell-cell contacts and thus involved in fate decisions of hESCs. Our results highlighted the important functional link between matrix rigidity, cellular mechanics, and pluripotency of hESCs and provided a novel approach to characterize and understand mechanotransduction and its involvement in hESC function. |
| doi_str_mv | 10.1371/journal.pone.0037178 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1324557497</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A477077185</galeid><doaj_id>oai_doaj_org_article_a639c639d1a2406aa33f02304d4de327</doaj_id><sourcerecordid>A477077185</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-730a4cea026ce60dbc75b115ca6b252695b64c0d045cbdd657096601994176813</originalsourceid><addsrcrecordid>eNqNkluL1DAUx4so7u7oNxAtCKIPM-ae6Yu4LF4GVha8vYY0Oe1kaJsxaWX325s63WUq-yAhF05_55-c03-WPcNohanEb3d-CJ1uVnvfwQqhFJLrB9kpLihZCoLow6PzSXYW4w4hTtdCPM5OCBGYFxSdZu-_gNnqzpmYB6iHRvcQ8yqtuQXjovNdzH2Vb4dWdzm0ZbjxCc5jD21uoGnik-xRpZsIT6d9kf34-OH7xefl5dWnzcX55dJIvu6XkiLNDGhEhAGBbJnCJcbcaFESTkTBS8EMsohxU1oruESFEAgXBcNSrDFdZC8OuvvGRzUVHxWmhHEuWSETsTkQ1uud2gfX6nCjvHbqb8CHWunQO9OA0oIWJk2LNWFIaE1phQhFzDILlIxa76bbhrIFa6Drg25movMvnduq2v9WlKYeFyIJvJ4Egv81QOxV6-LYMN2BH9K7EeZMSJnwRfbyH_T-6iaq1qkA11U-3WtGUXXOpERS4vWotbqHSsNC60xySuVSfJbwZpaQmB6u-1oPMarNt6__z179nLOvjtgt6KbfRt8M_eioOcgOoAk-xgDVXZMxUqPRb7uhRqOryegp7fnxD7pLunU2_QMW4vX-</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1324557497</pqid></control><display><type>article</type><title>Mechanics regulates fate decisions of human embryonic stem cells</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Sun, Yubing ; Villa-Diaz, Luis G ; Lam, Raymond H W ; Chen, Weiqiang ; Krebsbach, Paul H ; Fu, Jianping</creator><contributor>Lako, Majlinda</contributor><creatorcontrib>Sun, Yubing ; Villa-Diaz, Luis G ; Lam, Raymond H W ; Chen, Weiqiang ; Krebsbach, Paul H ; Fu, Jianping ; Lako, Majlinda</creatorcontrib><description>Research on human embryonic stem cells (hESCs) has attracted much attention given their great potential for tissue regenerative therapy and fundamental developmental biology studies. Yet, there is still limited understanding of how mechanical signals in the local cellular microenvironment of hESCs regulate their fate decisions. Here, we applied a microfabricated micromechanical platform to investigate the mechanoresponsive behaviors of hESCs. We demonstrated that hESCs are mechanosensitive, and they could increase their cytoskeleton contractility with matrix rigidity. Furthermore, rigid substrates supported maintenance of pluripotency of hESCs. Matrix mechanics-mediated cytoskeleton contractility might be functionally correlated with E-cadherin expressions in cell-cell contacts and thus involved in fate decisions of hESCs. Our results highlighted the important functional link between matrix rigidity, cellular mechanics, and pluripotency of hESCs and provided a novel approach to characterize and understand mechanotransduction and its involvement in hESC function.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0037178</identifier><identifier>PMID: 22615930</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology ; Biomechanics ; Biomedical engineering ; Cadherins - biosynthesis ; Cell Communication ; Cell Differentiation - physiology ; Contractility ; Cytoskeleton ; Cytoskeleton - physiology ; Decisions ; Developmental biology ; Dimethylpolysiloxanes ; E-cadherin ; Embryo cells ; Embryonic stem cells ; Embryonic Stem Cells - drug effects ; Embryonic Stem Cells - physiology ; Embryos ; Heterocyclic Compounds, 4 or More Rings - pharmacology ; Humans ; Insulin-like growth factors ; Kinases ; Laboratories ; Materials Science ; Mechanical engineering ; Mechanical stimuli ; Mechanics (physics) ; Mechanotransduction ; Mechanotransduction, Cellular - physiology ; Motility ; Nylons ; Octamer Transcription Factor-3 - biosynthesis ; Pluripotency ; Pluripotent Stem Cells - physiology ; Polymers ; Rigidity ; Rodents ; Stem cell research ; Stem cells ; Studies ; Substrates</subject><ispartof>PloS one, 2012-05, Vol.7 (5), p.e37178-e37178</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Sun et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Sun et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-730a4cea026ce60dbc75b115ca6b252695b64c0d045cbdd657096601994176813</citedby><cites>FETCH-LOGICAL-c758t-730a4cea026ce60dbc75b115ca6b252695b64c0d045cbdd657096601994176813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353896/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353896/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22615930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lako, Majlinda</contributor><creatorcontrib>Sun, Yubing</creatorcontrib><creatorcontrib>Villa-Diaz, Luis G</creatorcontrib><creatorcontrib>Lam, Raymond H W</creatorcontrib><creatorcontrib>Chen, Weiqiang</creatorcontrib><creatorcontrib>Krebsbach, Paul H</creatorcontrib><creatorcontrib>Fu, Jianping</creatorcontrib><title>Mechanics regulates fate decisions of human embryonic stem cells</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Research on human embryonic stem cells (hESCs) has attracted much attention given their great potential for tissue regenerative therapy and fundamental developmental biology studies. Yet, there is still limited understanding of how mechanical signals in the local cellular microenvironment of hESCs regulate their fate decisions. Here, we applied a microfabricated micromechanical platform to investigate the mechanoresponsive behaviors of hESCs. We demonstrated that hESCs are mechanosensitive, and they could increase their cytoskeleton contractility with matrix rigidity. Furthermore, rigid substrates supported maintenance of pluripotency of hESCs. Matrix mechanics-mediated cytoskeleton contractility might be functionally correlated with E-cadherin expressions in cell-cell contacts and thus involved in fate decisions of hESCs. Our results highlighted the important functional link between matrix rigidity, cellular mechanics, and pluripotency of hESCs and provided a novel approach to characterize and understand mechanotransduction and its involvement in hESC function.</description><subject>Biology</subject><subject>Biomechanics</subject><subject>Biomedical engineering</subject><subject>Cadherins - biosynthesis</subject><subject>Cell Communication</subject><subject>Cell Differentiation - physiology</subject><subject>Contractility</subject><subject>Cytoskeleton</subject><subject>Cytoskeleton - physiology</subject><subject>Decisions</subject><subject>Developmental biology</subject><subject>Dimethylpolysiloxanes</subject><subject>E-cadherin</subject><subject>Embryo cells</subject><subject>Embryonic stem cells</subject><subject>Embryonic Stem Cells - drug effects</subject><subject>Embryonic Stem Cells - physiology</subject><subject>Embryos</subject><subject>Heterocyclic Compounds, 4 or More Rings - pharmacology</subject><subject>Humans</subject><subject>Insulin-like growth factors</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Materials Science</subject><subject>Mechanical engineering</subject><subject>Mechanical stimuli</subject><subject>Mechanics (physics)</subject><subject>Mechanotransduction</subject><subject>Mechanotransduction, Cellular - physiology</subject><subject>Motility</subject><subject>Nylons</subject><subject>Octamer Transcription Factor-3 - biosynthesis</subject><subject>Pluripotency</subject><subject>Pluripotent Stem Cells - physiology</subject><subject>Polymers</subject><subject>Rigidity</subject><subject>Rodents</subject><subject>Stem cell research</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Substrates</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkluL1DAUx4so7u7oNxAtCKIPM-ae6Yu4LF4GVha8vYY0Oe1kaJsxaWX325s63WUq-yAhF05_55-c03-WPcNohanEb3d-CJ1uVnvfwQqhFJLrB9kpLihZCoLow6PzSXYW4w4hTtdCPM5OCBGYFxSdZu-_gNnqzpmYB6iHRvcQ8yqtuQXjovNdzH2Vb4dWdzm0ZbjxCc5jD21uoGnik-xRpZsIT6d9kf34-OH7xefl5dWnzcX55dJIvu6XkiLNDGhEhAGBbJnCJcbcaFESTkTBS8EMsohxU1oruESFEAgXBcNSrDFdZC8OuvvGRzUVHxWmhHEuWSETsTkQ1uud2gfX6nCjvHbqb8CHWunQO9OA0oIWJk2LNWFIaE1phQhFzDILlIxa76bbhrIFa6Drg25movMvnduq2v9WlKYeFyIJvJ4Egv81QOxV6-LYMN2BH9K7EeZMSJnwRfbyH_T-6iaq1qkA11U-3WtGUXXOpERS4vWotbqHSsNC60xySuVSfJbwZpaQmB6u-1oPMarNt6__z179nLOvjtgt6KbfRt8M_eioOcgOoAk-xgDVXZMxUqPRb7uhRqOryegp7fnxD7pLunU2_QMW4vX-</recordid><startdate>20120516</startdate><enddate>20120516</enddate><creator>Sun, Yubing</creator><creator>Villa-Diaz, Luis G</creator><creator>Lam, Raymond H W</creator><creator>Chen, Weiqiang</creator><creator>Krebsbach, Paul H</creator><creator>Fu, Jianping</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120516</creationdate><title>Mechanics regulates fate decisions of human embryonic stem cells</title><author>Sun, Yubing ; Villa-Diaz, Luis G ; Lam, Raymond H W ; Chen, Weiqiang ; Krebsbach, Paul H ; Fu, Jianping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-730a4cea026ce60dbc75b115ca6b252695b64c0d045cbdd657096601994176813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biology</topic><topic>Biomechanics</topic><topic>Biomedical engineering</topic><topic>Cadherins - biosynthesis</topic><topic>Cell Communication</topic><topic>Cell Differentiation - physiology</topic><topic>Contractility</topic><topic>Cytoskeleton</topic><topic>Cytoskeleton - physiology</topic><topic>Decisions</topic><topic>Developmental biology</topic><topic>Dimethylpolysiloxanes</topic><topic>E-cadherin</topic><topic>Embryo cells</topic><topic>Embryonic stem cells</topic><topic>Embryonic Stem Cells - drug effects</topic><topic>Embryonic Stem Cells - physiology</topic><topic>Embryos</topic><topic>Heterocyclic Compounds, 4 or More Rings - pharmacology</topic><topic>Humans</topic><topic>Insulin-like growth factors</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Materials Science</topic><topic>Mechanical engineering</topic><topic>Mechanical stimuli</topic><topic>Mechanics (physics)</topic><topic>Mechanotransduction</topic><topic>Mechanotransduction, Cellular - physiology</topic><topic>Motility</topic><topic>Nylons</topic><topic>Octamer Transcription Factor-3 - biosynthesis</topic><topic>Pluripotency</topic><topic>Pluripotent Stem Cells - physiology</topic><topic>Polymers</topic><topic>Rigidity</topic><topic>Rodents</topic><topic>Stem cell research</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Yubing</creatorcontrib><creatorcontrib>Villa-Diaz, Luis G</creatorcontrib><creatorcontrib>Lam, Raymond H W</creatorcontrib><creatorcontrib>Chen, Weiqiang</creatorcontrib><creatorcontrib>Krebsbach, Paul H</creatorcontrib><creatorcontrib>Fu, Jianping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Yubing</au><au>Villa-Diaz, Luis G</au><au>Lam, Raymond H W</au><au>Chen, Weiqiang</au><au>Krebsbach, Paul H</au><au>Fu, Jianping</au><au>Lako, Majlinda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanics regulates fate decisions of human embryonic stem cells</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-05-16</date><risdate>2012</risdate><volume>7</volume><issue>5</issue><spage>e37178</spage><epage>e37178</epage><pages>e37178-e37178</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Research on human embryonic stem cells (hESCs) has attracted much attention given their great potential for tissue regenerative therapy and fundamental developmental biology studies. Yet, there is still limited understanding of how mechanical signals in the local cellular microenvironment of hESCs regulate their fate decisions. Here, we applied a microfabricated micromechanical platform to investigate the mechanoresponsive behaviors of hESCs. We demonstrated that hESCs are mechanosensitive, and they could increase their cytoskeleton contractility with matrix rigidity. Furthermore, rigid substrates supported maintenance of pluripotency of hESCs. Matrix mechanics-mediated cytoskeleton contractility might be functionally correlated with E-cadherin expressions in cell-cell contacts and thus involved in fate decisions of hESCs. Our results highlighted the important functional link between matrix rigidity, cellular mechanics, and pluripotency of hESCs and provided a novel approach to characterize and understand mechanotransduction and its involvement in hESC function.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22615930</pmid><doi>10.1371/journal.pone.0037178</doi><tpages>e37178</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-05, Vol.7 (5), p.e37178-e37178 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1324557497 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Biology Biomechanics Biomedical engineering Cadherins - biosynthesis Cell Communication Cell Differentiation - physiology Contractility Cytoskeleton Cytoskeleton - physiology Decisions Developmental biology Dimethylpolysiloxanes E-cadherin Embryo cells Embryonic stem cells Embryonic Stem Cells - drug effects Embryonic Stem Cells - physiology Embryos Heterocyclic Compounds, 4 or More Rings - pharmacology Humans Insulin-like growth factors Kinases Laboratories Materials Science Mechanical engineering Mechanical stimuli Mechanics (physics) Mechanotransduction Mechanotransduction, Cellular - physiology Motility Nylons Octamer Transcription Factor-3 - biosynthesis Pluripotency Pluripotent Stem Cells - physiology Polymers Rigidity Rodents Stem cell research Stem cells Studies Substrates |
| title | Mechanics regulates fate decisions of human embryonic stem cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T06%3A12%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanics%20regulates%20fate%20decisions%20of%20human%20embryonic%20stem%20cells&rft.jtitle=PloS%20one&rft.au=Sun,%20Yubing&rft.date=2012-05-16&rft.volume=7&rft.issue=5&rft.spage=e37178&rft.epage=e37178&rft.pages=e37178-e37178&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0037178&rft_dat=%3Cgale_plos_%3EA477077185%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1324557497&rft_id=info:pmid/22615930&rft_galeid=A477077185&rft_doaj_id=oai_doaj_org_article_a639c639d1a2406aa33f02304d4de327&rfr_iscdi=true |