Down-regulation of AP-4 inhibits proliferation, induces cell cycle arrest and promotes apoptosis in human gastric cancer cells

AP-4 belongs to the basic helix-loop-helix leucine-zipper subgroup; it controls target gene expression, regulates growth, development and cell apoptosis and has been implicated in tumorigenesis. Our previous studies indicated that AP-4 was frequently overexpressed in gastric cancers and may be assoc...

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Veröffentlicht in:	PloS one 2012-05, Vol.7 (5), p.e37096-e37096
Hauptverfasser:	Liu, Xinghua, Zhang, Bo, Guo, Yan, Liang, Qi, Wu, Changyao, Wu, Lei, Tao, Kaixiong, Wang, Guobin, Chen, Jianying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex 4 - genetics Adaptor Protein Complex 4 - metabolism Antineoplastic drugs Antitumor agents Apoptosis Apoptosis - genetics Arthritis Assaying Bcl-2 protein Bcl-x protein bcl-X Protein - genetics bcl-X Protein - metabolism Biology Breast cancer Cancer Cancer cells Caspase Caspase 9 - genetics Caspase 9 - metabolism Caspase-9 Cell cycle Cell Cycle Checkpoints - genetics Cell growth Cell Growth Processes - genetics Cell Line, Tumor Cell proliferation Chemotherapy Cholecystokinin Cooperation Cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cytokines Deoxyribonucleic acid DNA Down-Regulation Drugs Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Gene silencing Genes Genetic engineering Growth factors Helix-loop-helix proteins Helix-loop-helix proteins (basic) Hospitals Humans Leucine Leucine zipper proteins Maternal & child health Medical prognosis Medicine Mucosa p53 Protein Phosphorylation Physics Prognosis Proteins Proto-Oncogene Proteins c-bcl-2 Real time Regulators RNA RNA, Messenger - genetics RNA, Small Interfering - genetics Science siRNA Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Surgery Transcription factors Transfection Tumor cell lines Tumor proteins Tumorigenesis
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