Direct observation of strand passage by DNA-topoisomerase and its limited processivity

Type-II DNA topoisomerases resolve DNA entanglements such as supercoils, knots and catenanes by passing one segment of DNA duplex through a transient enzyme-bridged double-stranded break in another segment. The ATP-dependent passage reaction has previously been demonstrated at the single-molecule le...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e34920-e34920
Hauptverfasser:	Yogo, Katsunori, Ogawa, Taisaku, Hayashi, Masahito, Harada, Yoshie, Nishizaka, Takayuki, Kinosita, Jr, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - chemistry Antigens, Neoplasm - metabolism ATP Binding Sites Biology Biophysics Braiding Catenanes Deoxyribonucleic acid DNA DNA - metabolism DNA topoisomerase DNA topoisomerase (ATP-hydrolysing) DNA Topoisomerases, Type II - chemistry DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism E coli Enzymes Escherichia coli Exhaustion Fluorescence Geometry Humans Knots Physics Science
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