Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells

In the current study, we assessed the global DNA methylation changes in human lymphoblastoid (TK6) cells in vitro in response to 5 direct and 10 indirect-acting genotoxic agents. TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2012-04, Vol.7 (4), p.e34674
Hauptverfasser: Tabish, Ali M, Poels, Katrien, Hoet, Peter, Godderis, Lode
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 4
container_start_page e34674
container_title PloS one
container_volume 7
creator Tabish, Ali M
Poels, Katrien
Hoet, Peter
Godderis, Lode
description In the current study, we assessed the global DNA methylation changes in human lymphoblastoid (TK6) cells in vitro in response to 5 direct and 10 indirect-acting genotoxic agents. TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromatography-mass spectrometry was used for quantitative profiling of 5-methyl-2'-deoxycytidine. The effect of exposure on 5-methyl-2'-deoxycytidine between control and exposed cultures was assessed by applying the marginal model with correlated residuals on % global DNA methylation data. We reported the induction of global DNA hypomethylation in TK6 cells in response to S9 metabolic mix, under the current experimental settings. Benzene, hydroquinone, styrene, carbon tetrachloride and trichloroethylene induced global DNA hypomethylation in TK6 cells. Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic.
doi_str_mv 10.1371/journal.pone.0034674
format Article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1324448543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A477133347</galeid><doaj_id>oai_doaj_org_article_d13209c1b9bd4114a292704d0478533f</doaj_id><sourcerecordid>A477133347</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-6eb691293f83d43b223976535a0f2adc5ef213a6558b100a62292e66067e8d8a3</originalsourceid><addsrcrecordid>eNqNkl2L1DAYhYso7rr6D0QLguDFjPlq2nohDOuqg4sLunob0jRps6bJmKSL--9Nne4yBQXpRcub55y8nJ4sewrBGuISvr5yo7fcrHfOyjUAmNCS3MuOYY3RiiKA7x98H2WPQrgCoMAVpQ-zI4QKUGNCjrPrs53upJVRi1xxEZ0Puba54FZIn3sdfrzJpVJSxNypXPRy0IKbdO6Fti4pQ-5s3hnXpOm7z5t8kLG_MTzqNN7xGKW3k2E_Dtzml59oLqQx4XH2QHET5JP5fZJ9e392efpxdX7xYXu6OV8JWqO4orKhNUQ1VhVuCW4QwnVJC1xwoBBvRSEVgpjToqgaCACnCNVIUgpoKau24vgke7733RkX2BxZYBAjQkhVEJyI7Z5oHb9iO68H7m-Y45r9GTjfMe5TOkayNslALWBTNy2BkPB0WQlIC0hZFRir5PV2vm1sBtkKaaPnZmG6PLG6Z527Znjap6qSwYvZwLufowzxHyvPVMfTVtoql8zEoINgG1KWEGNMykSt_0Klp53-YSqN0mm-ELxaCBIT5a_Y8TEEtv365f_Zi-9L9uUB20tuYh-cGaeKhCVI9qDwLgQv1V1yELCp87dpsKnzbO58kj07TP1OdFty_BvDz_p2</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1324448543</pqid></control><display><type>article</type><title>Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Tabish, Ali M ; Poels, Katrien ; Hoet, Peter ; Godderis, Lode</creator><creatorcontrib>Tabish, Ali M ; Poels, Katrien ; Hoet, Peter ; Godderis, Lode</creatorcontrib><description>In the current study, we assessed the global DNA methylation changes in human lymphoblastoid (TK6) cells in vitro in response to 5 direct and 10 indirect-acting genotoxic agents. TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromatography-mass spectrometry was used for quantitative profiling of 5-methyl-2'-deoxycytidine. The effect of exposure on 5-methyl-2'-deoxycytidine between control and exposed cultures was assessed by applying the marginal model with correlated residuals on % global DNA methylation data. We reported the induction of global DNA hypomethylation in TK6 cells in response to S9 metabolic mix, under the current experimental settings. Benzene, hydroquinone, styrene, carbon tetrachloride and trichloroethylene induced global DNA hypomethylation in TK6 cells. Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0034674</identifier><identifier>PMID: 22509344</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Benzene ; Biology ; Cancer ; Cancer genetics ; Carbon tetrachloride ; Carcinogens ; Carcinogens - pharmacology ; Carcinogens - toxicity ; Cell Line ; Cell Transformation, Neoplastic - drug effects ; Cell Transformation, Neoplastic - genetics ; Chromatography ; Deoxycytidine - analogs &amp; derivatives ; Deoxycytidine - toxicity ; Deoxyribonucleic acid ; Development and progression ; DNA ; DNA methylation ; DNA Methylation - drug effects ; DNA Methylation - genetics ; Dose-Response Relationship, Drug ; Epigenesis, Genetic - drug effects ; Epigenesis, Genetic - genetics ; Epigenetic inheritance ; Epigenetics ; Exposure ; Genetic research ; Genotoxicity ; Health aspects ; Health risks ; Humans ; Hydroquinone ; Kinases ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; Metabolites ; Methylation ; Mutagenicity Tests ; Mutation ; Neoplasms - etiology ; Neoplasms - genetics ; Neoplasms - metabolism ; Risk Factors ; Solvents ; Styrene ; Trichloroethylene</subject><ispartof>PloS one, 2012-04, Vol.7 (4), p.e34674</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Tabish et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Tabish et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6eb691293f83d43b223976535a0f2adc5ef213a6558b100a62292e66067e8d8a3</citedby><cites>FETCH-LOGICAL-c692t-6eb691293f83d43b223976535a0f2adc5ef213a6558b100a62292e66067e8d8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324488/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324488/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22509344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabish, Ali M</creatorcontrib><creatorcontrib>Poels, Katrien</creatorcontrib><creatorcontrib>Hoet, Peter</creatorcontrib><creatorcontrib>Godderis, Lode</creatorcontrib><title>Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In the current study, we assessed the global DNA methylation changes in human lymphoblastoid (TK6) cells in vitro in response to 5 direct and 10 indirect-acting genotoxic agents. TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromatography-mass spectrometry was used for quantitative profiling of 5-methyl-2'-deoxycytidine. The effect of exposure on 5-methyl-2'-deoxycytidine between control and exposed cultures was assessed by applying the marginal model with correlated residuals on % global DNA methylation data. We reported the induction of global DNA hypomethylation in TK6 cells in response to S9 metabolic mix, under the current experimental settings. Benzene, hydroquinone, styrene, carbon tetrachloride and trichloroethylene induced global DNA hypomethylation in TK6 cells. Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic.</description><subject>Benzene</subject><subject>Biology</subject><subject>Cancer</subject><subject>Cancer genetics</subject><subject>Carbon tetrachloride</subject><subject>Carcinogens</subject><subject>Carcinogens - pharmacology</subject><subject>Carcinogens - toxicity</subject><subject>Cell Line</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Chromatography</subject><subject>Deoxycytidine - analogs &amp; derivatives</subject><subject>Deoxycytidine - toxicity</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA Methylation - drug effects</subject><subject>DNA Methylation - genetics</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epigenesis, Genetic - drug effects</subject><subject>Epigenesis, Genetic - genetics</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Exposure</subject><subject>Genetic research</subject><subject>Genotoxicity</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Hydroquinone</subject><subject>Kinases</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolites</subject><subject>Methylation</subject><subject>Mutagenicity Tests</subject><subject>Mutation</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Risk Factors</subject><subject>Solvents</subject><subject>Styrene</subject><subject>Trichloroethylene</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAYhYso7rr6D0QLguDFjPlq2nohDOuqg4sLunob0jRps6bJmKSL--9Nne4yBQXpRcub55y8nJ4sewrBGuISvr5yo7fcrHfOyjUAmNCS3MuOYY3RiiKA7x98H2WPQrgCoMAVpQ-zI4QKUGNCjrPrs53upJVRi1xxEZ0Puba54FZIn3sdfrzJpVJSxNypXPRy0IKbdO6Fti4pQ-5s3hnXpOm7z5t8kLG_MTzqNN7xGKW3k2E_Dtzml59oLqQx4XH2QHET5JP5fZJ9e392efpxdX7xYXu6OV8JWqO4orKhNUQ1VhVuCW4QwnVJC1xwoBBvRSEVgpjToqgaCACnCNVIUgpoKau24vgke7733RkX2BxZYBAjQkhVEJyI7Z5oHb9iO68H7m-Y45r9GTjfMe5TOkayNslALWBTNy2BkPB0WQlIC0hZFRir5PV2vm1sBtkKaaPnZmG6PLG6Z527Znjap6qSwYvZwLufowzxHyvPVMfTVtoql8zEoINgG1KWEGNMykSt_0Klp53-YSqN0mm-ELxaCBIT5a_Y8TEEtv365f_Zi-9L9uUB20tuYh-cGaeKhCVI9qDwLgQv1V1yELCp87dpsKnzbO58kj07TP1OdFty_BvDz_p2</recordid><startdate>20120411</startdate><enddate>20120411</enddate><creator>Tabish, Ali M</creator><creator>Poels, Katrien</creator><creator>Hoet, Peter</creator><creator>Godderis, Lode</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120411</creationdate><title>Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells</title><author>Tabish, Ali M ; Poels, Katrien ; Hoet, Peter ; Godderis, Lode</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6eb691293f83d43b223976535a0f2adc5ef213a6558b100a62292e66067e8d8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Benzene</topic><topic>Biology</topic><topic>Cancer</topic><topic>Cancer genetics</topic><topic>Carbon tetrachloride</topic><topic>Carcinogens</topic><topic>Carcinogens - pharmacology</topic><topic>Carcinogens - toxicity</topic><topic>Cell Line</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Chromatography</topic><topic>Deoxycytidine - analogs &amp; derivatives</topic><topic>Deoxycytidine - toxicity</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>DNA Methylation - drug effects</topic><topic>DNA Methylation - genetics</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epigenesis, Genetic - drug effects</topic><topic>Epigenesis, Genetic - genetics</topic><topic>Epigenetic inheritance</topic><topic>Epigenetics</topic><topic>Exposure</topic><topic>Genetic research</topic><topic>Genotoxicity</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Humans</topic><topic>Hydroquinone</topic><topic>Kinases</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Metabolites</topic><topic>Methylation</topic><topic>Mutagenicity Tests</topic><topic>Mutation</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Risk Factors</topic><topic>Solvents</topic><topic>Styrene</topic><topic>Trichloroethylene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabish, Ali M</creatorcontrib><creatorcontrib>Poels, Katrien</creatorcontrib><creatorcontrib>Hoet, Peter</creatorcontrib><creatorcontrib>Godderis, Lode</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabish, Ali M</au><au>Poels, Katrien</au><au>Hoet, Peter</au><au>Godderis, Lode</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-04-11</date><risdate>2012</risdate><volume>7</volume><issue>4</issue><spage>e34674</spage><pages>e34674-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In the current study, we assessed the global DNA methylation changes in human lymphoblastoid (TK6) cells in vitro in response to 5 direct and 10 indirect-acting genotoxic agents. TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromatography-mass spectrometry was used for quantitative profiling of 5-methyl-2'-deoxycytidine. The effect of exposure on 5-methyl-2'-deoxycytidine between control and exposed cultures was assessed by applying the marginal model with correlated residuals on % global DNA methylation data. We reported the induction of global DNA hypomethylation in TK6 cells in response to S9 metabolic mix, under the current experimental settings. Benzene, hydroquinone, styrene, carbon tetrachloride and trichloroethylene induced global DNA hypomethylation in TK6 cells. Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22509344</pmid><doi>10.1371/journal.pone.0034674</doi><tpages>e34674</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2012-04, Vol.7 (4), p.e34674
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1324448543
source MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS)
subjects Benzene
Biology
Cancer
Cancer genetics
Carbon tetrachloride
Carcinogens
Carcinogens - pharmacology
Carcinogens - toxicity
Cell Line
Cell Transformation, Neoplastic - drug effects
Cell Transformation, Neoplastic - genetics
Chromatography
Deoxycytidine - analogs & derivatives
Deoxycytidine - toxicity
Deoxyribonucleic acid
Development and progression
DNA
DNA methylation
DNA Methylation - drug effects
DNA Methylation - genetics
Dose-Response Relationship, Drug
Epigenesis, Genetic - drug effects
Epigenesis, Genetic - genetics
Epigenetic inheritance
Epigenetics
Exposure
Genetic research
Genotoxicity
Health aspects
Health risks
Humans
Hydroquinone
Kinases
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolites
Methylation
Mutagenicity Tests
Mutation
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - metabolism
Risk Factors
Solvents
Styrene
Trichloroethylene
title Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T11%3A19%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epigenetic%20factors%20in%20cancer%20risk:%20effect%20of%20chemical%20carcinogens%20on%20global%20DNA%20methylation%20pattern%20in%20human%20TK6%20cells&rft.jtitle=PloS%20one&rft.au=Tabish,%20Ali%20M&rft.date=2012-04-11&rft.volume=7&rft.issue=4&rft.spage=e34674&rft.pages=e34674-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0034674&rft_dat=%3Cgale_plos_%3EA477133347%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1324448543&rft_id=info:pmid/22509344&rft_galeid=A477133347&rft_doaj_id=oai_doaj_org_article_d13209c1b9bd4114a292704d0478533f&rfr_iscdi=true