Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells
In the current study, we assessed the global DNA methylation changes in human lymphoblastoid (TK6) cells in vitro in response to 5 direct and 10 indirect-acting genotoxic agents. TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromat...
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description | In the current study, we assessed the global DNA methylation changes in human lymphoblastoid (TK6) cells in vitro in response to 5 direct and 10 indirect-acting genotoxic agents. TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromatography-mass spectrometry was used for quantitative profiling of 5-methyl-2'-deoxycytidine. The effect of exposure on 5-methyl-2'-deoxycytidine between control and exposed cultures was assessed by applying the marginal model with correlated residuals on % global DNA methylation data. We reported the induction of global DNA hypomethylation in TK6 cells in response to S9 metabolic mix, under the current experimental settings. Benzene, hydroquinone, styrene, carbon tetrachloride and trichloroethylene induced global DNA hypomethylation in TK6 cells. Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic. |
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TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromatography-mass spectrometry was used for quantitative profiling of 5-methyl-2'-deoxycytidine. The effect of exposure on 5-methyl-2'-deoxycytidine between control and exposed cultures was assessed by applying the marginal model with correlated residuals on % global DNA methylation data. We reported the induction of global DNA hypomethylation in TK6 cells in response to S9 metabolic mix, under the current experimental settings. Benzene, hydroquinone, styrene, carbon tetrachloride and trichloroethylene induced global DNA hypomethylation in TK6 cells. Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0034674</identifier><identifier>PMID: 22509344</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Benzene ; Biology ; Cancer ; Cancer genetics ; Carbon tetrachloride ; Carcinogens ; Carcinogens - pharmacology ; Carcinogens - toxicity ; Cell Line ; Cell Transformation, Neoplastic - drug effects ; Cell Transformation, Neoplastic - genetics ; Chromatography ; Deoxycytidine - analogs & derivatives ; Deoxycytidine - toxicity ; Deoxyribonucleic acid ; Development and progression ; DNA ; DNA methylation ; DNA Methylation - drug effects ; DNA Methylation - genetics ; Dose-Response Relationship, Drug ; Epigenesis, Genetic - drug effects ; Epigenesis, Genetic - genetics ; Epigenetic inheritance ; Epigenetics ; Exposure ; Genetic research ; Genotoxicity ; Health aspects ; Health risks ; Humans ; Hydroquinone ; Kinases ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; Metabolites ; Methylation ; Mutagenicity Tests ; Mutation ; Neoplasms - etiology ; Neoplasms - genetics ; Neoplasms - metabolism ; Risk Factors ; Solvents ; Styrene ; Trichloroethylene</subject><ispartof>PloS one, 2012-04, Vol.7 (4), p.e34674</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Tabish et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Tabish et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6eb691293f83d43b223976535a0f2adc5ef213a6558b100a62292e66067e8d8a3</citedby><cites>FETCH-LOGICAL-c692t-6eb691293f83d43b223976535a0f2adc5ef213a6558b100a62292e66067e8d8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324488/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324488/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22509344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabish, Ali M</creatorcontrib><creatorcontrib>Poels, Katrien</creatorcontrib><creatorcontrib>Hoet, Peter</creatorcontrib><creatorcontrib>Godderis, Lode</creatorcontrib><title>Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In the current study, we assessed the global DNA methylation changes in human lymphoblastoid (TK6) cells in vitro in response to 5 direct and 10 indirect-acting genotoxic agents. TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromatography-mass spectrometry was used for quantitative profiling of 5-methyl-2'-deoxycytidine. The effect of exposure on 5-methyl-2'-deoxycytidine between control and exposed cultures was assessed by applying the marginal model with correlated residuals on % global DNA methylation data. We reported the induction of global DNA hypomethylation in TK6 cells in response to S9 metabolic mix, under the current experimental settings. Benzene, hydroquinone, styrene, carbon tetrachloride and trichloroethylene induced global DNA hypomethylation in TK6 cells. Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic.</description><subject>Benzene</subject><subject>Biology</subject><subject>Cancer</subject><subject>Cancer genetics</subject><subject>Carbon tetrachloride</subject><subject>Carcinogens</subject><subject>Carcinogens - pharmacology</subject><subject>Carcinogens - toxicity</subject><subject>Cell Line</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Chromatography</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>Deoxycytidine - toxicity</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA Methylation - drug effects</subject><subject>DNA Methylation - genetics</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epigenesis, Genetic - drug effects</subject><subject>Epigenesis, Genetic - genetics</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Exposure</subject><subject>Genetic research</subject><subject>Genotoxicity</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Hydroquinone</subject><subject>Kinases</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolites</subject><subject>Methylation</subject><subject>Mutagenicity Tests</subject><subject>Mutation</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Risk Factors</subject><subject>Solvents</subject><subject>Styrene</subject><subject>Trichloroethylene</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAYhYso7rr6D0QLguDFjPlq2nohDOuqg4sLunob0jRps6bJmKSL--9Nne4yBQXpRcub55y8nJ4sewrBGuISvr5yo7fcrHfOyjUAmNCS3MuOYY3RiiKA7x98H2WPQrgCoMAVpQ-zI4QKUGNCjrPrs53upJVRi1xxEZ0Puba54FZIn3sdfrzJpVJSxNypXPRy0IKbdO6Fti4pQ-5s3hnXpOm7z5t8kLG_MTzqNN7xGKW3k2E_Dtzml59oLqQx4XH2QHET5JP5fZJ9e392efpxdX7xYXu6OV8JWqO4orKhNUQ1VhVuCW4QwnVJC1xwoBBvRSEVgpjToqgaCACnCNVIUgpoKau24vgke7733RkX2BxZYBAjQkhVEJyI7Z5oHb9iO68H7m-Y45r9GTjfMe5TOkayNslALWBTNy2BkPB0WQlIC0hZFRir5PV2vm1sBtkKaaPnZmG6PLG6Z527Znjap6qSwYvZwLufowzxHyvPVMfTVtoql8zEoINgG1KWEGNMykSt_0Klp53-YSqN0mm-ELxaCBIT5a_Y8TEEtv365f_Zi-9L9uUB20tuYh-cGaeKhCVI9qDwLgQv1V1yELCp87dpsKnzbO58kj07TP1OdFty_BvDz_p2</recordid><startdate>20120411</startdate><enddate>20120411</enddate><creator>Tabish, Ali M</creator><creator>Poels, Katrien</creator><creator>Hoet, Peter</creator><creator>Godderis, Lode</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120411</creationdate><title>Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells</title><author>Tabish, Ali M ; Poels, Katrien ; Hoet, Peter ; Godderis, Lode</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6eb691293f83d43b223976535a0f2adc5ef213a6558b100a62292e66067e8d8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Benzene</topic><topic>Biology</topic><topic>Cancer</topic><topic>Cancer genetics</topic><topic>Carbon tetrachloride</topic><topic>Carcinogens</topic><topic>Carcinogens - pharmacology</topic><topic>Carcinogens - toxicity</topic><topic>Cell Line</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Chromatography</topic><topic>Deoxycytidine - analogs & derivatives</topic><topic>Deoxycytidine - toxicity</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>DNA Methylation - drug effects</topic><topic>DNA Methylation - genetics</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epigenesis, Genetic - drug effects</topic><topic>Epigenesis, Genetic - genetics</topic><topic>Epigenetic inheritance</topic><topic>Epigenetics</topic><topic>Exposure</topic><topic>Genetic research</topic><topic>Genotoxicity</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Humans</topic><topic>Hydroquinone</topic><topic>Kinases</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Metabolites</topic><topic>Methylation</topic><topic>Mutagenicity Tests</topic><topic>Mutation</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Risk Factors</topic><topic>Solvents</topic><topic>Styrene</topic><topic>Trichloroethylene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabish, Ali M</creatorcontrib><creatorcontrib>Poels, Katrien</creatorcontrib><creatorcontrib>Hoet, Peter</creatorcontrib><creatorcontrib>Godderis, Lode</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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TK6 cells were exposed to the selected agents for 24 h in the presence and/or absence of S9 metabolic mix. Liquid chromatography-mass spectrometry was used for quantitative profiling of 5-methyl-2'-deoxycytidine. The effect of exposure on 5-methyl-2'-deoxycytidine between control and exposed cultures was assessed by applying the marginal model with correlated residuals on % global DNA methylation data. We reported the induction of global DNA hypomethylation in TK6 cells in response to S9 metabolic mix, under the current experimental settings. Benzene, hydroquinone, styrene, carbon tetrachloride and trichloroethylene induced global DNA hypomethylation in TK6 cells. Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22509344</pmid><doi>10.1371/journal.pone.0034674</doi><tpages>e34674</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Benzene Biology Cancer Cancer genetics Carbon tetrachloride Carcinogens Carcinogens - pharmacology Carcinogens - toxicity Cell Line Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - genetics Chromatography Deoxycytidine - analogs & derivatives Deoxycytidine - toxicity Deoxyribonucleic acid Development and progression DNA DNA methylation DNA Methylation - drug effects DNA Methylation - genetics Dose-Response Relationship, Drug Epigenesis, Genetic - drug effects Epigenesis, Genetic - genetics Epigenetic inheritance Epigenetics Exposure Genetic research Genotoxicity Health aspects Health risks Humans Hydroquinone Kinases Liquid chromatography Mass spectrometry Mass spectroscopy Metabolites Methylation Mutagenicity Tests Mutation Neoplasms - etiology Neoplasms - genetics Neoplasms - metabolism Risk Factors Solvents Styrene Trichloroethylene |
title | Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells |
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