Miiuy croaker hepcidin gene and comparative analyses reveal evidence for positive selection

Hepcidin antimicrobial peptide (HAMP) is a small cysteine-rich peptide and a key molecule of the innate immune system against bacterial infections. Molecular cloning and genomic characterization of HAMP gene in the miiuy croaker (Miichthys miiuy) were reported in this study. The miiuy croaker HAMP w...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35449-e35449
Hauptverfasser:	Xu, Tianjun, Sun, Yuena, Shi, Ge, Wang, Rixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Analysis Animals Antimicrobial agents Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - physiology Bacteria Bacterial infections Base Sequence Biodiversity Biological evolution Biology Cloning Cloning, Molecular Cysteine Cystine Engineering Evolution Evolution, Molecular Evolutionary genetics Exons Fish Fish Proteins - genetics Fish Proteins - metabolism Fish Proteins - physiology Gene expression Gene regulation Genes Genetic aspects Genetic polymorphisms Health aspects Hepcidin Hepcidins Immune system Infection Innate immunity Intestine Introns Laboratories Liver Mammals Miichthys miiuy Model testing Molecular biology Molecular evolution Natural selection Paralichthys olivaceus Peptides Perciformes - genetics Phylogenetics Phylogeny Polymorphism Polymorphism, Genetic Positive selection Proteins Selection, Genetic Sequence Alignment Sequence Analysis, Protein Sequences Shellfish Species diversity Spleen Transcription Vibrio anguillarum Water-borne diseases Waterborne diseases
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