Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS

Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease characterized by loss of upper and lower motor neurons. ALS is considered to be a complex trait and genome-wide association studies (GWAS) have implicated a few susceptibility loci. However, many more causal loci remain...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35333-e35333
Hauptverfasser:	Diekstra, Frank P, Saris, Christiaan G J, van Rheenen, Wouter, Franke, Lude, Jansen, Ritsert C, van Es, Michael A, van Vught, Paul W J, Blauw, Hylke M, Groen, Ewout J N, Horvath, Steve, Estrada, Karol, Rivadeneira, Fernando, Hofman, Albert, Uitterlinden, Andre G, Robberecht, Wim, Andersen, Peter M, Melki, Judith, Meininger, Vincent, Hardiman, Orla, Landers, John E, Brown, Jr, Robert H, Shatunov, Aleksey, Shaw, Christopher E, Leigh, P Nigel, Al-Chalabi, Ammar, Ophoff, Roel A, van den Berg, Leonard H, Veldink, Jan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Analysis Arabidopsis Bioinformatics Biology Brain Cholestanetriol 26-Monooxygenase - genetics Councils Cytochrome P-450 Dementia Disease susceptibility DNA methylation Epidemiology Gene expression Gene Expression Profiling Gene mapping Genes Genetic aspects Genetic diversity Genetic Predisposition to Disease Genetic variance Genetics Genome-Wide Association Study Genomes Genomics Genotype Genotyping Haplotypes HapMap Project Hospitals Humans Linkage Disequilibrium Loci Medical research Medicine Metabolism Motor neurons Motor Neurons - pathology Mutation Nervous system diseases Neurodegeneration Neurology Neurosciences Patients Pedigree Peripheral blood Polymorphism, Single Nucleotide Psychiatry Quantitative Trait Loci - genetics Single-nucleotide polymorphism Stress response Transcription Xanthomatosis Xanthomatosis, Cerebrotendinous - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!