Preparation and characterization of the extracellular domain of human Sid-1

In C. elegans, the cell surface protein Sid-1 imports extracellular dsRNA into the cytosol of most non-neuronal cells, enabling systemic spread of RNA interference (RNAi) throughout the worm. Sid-1 homologs are found in many other animals, although for most a function for the protein has not yet bee...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e33607-e33607
Hauptverfasser:	Pratt, Ashley J, Rambo, Robert P, Lau, Pick-Wei, MacRae, Ian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Access control Animals Baculoviridae - genetics Baculovirus BASIC BIOLOGICAL SCIENCES Biology Caenorhabditis elegans Cell surface Crystallography Cytosol Data analysis Double-stranded RNA Electron microscopy Extracellular Space - metabolism Gene expression Genes Glycosylation Homology Humans Imports Insects Membrane Transport Proteins - chemistry Membrane Transport Proteins - genetics Membrane Transport Proteins - isolation & purification Membrane Transport Proteins - metabolism Models, Molecular Molecular biology Nematodes Physiology Potassium Protein Folding Protein Multimerization Protein Processing, Post-Translational protein structure protein structure prediction Protein Structure, Quaternary Protein Structure, Tertiary Proteins Pyrococcus horikoshii recombinant protein Ribonucleic acid RNA RNA structure RNA transport RNA-mediated interference Sequence Homology, Amino Acid small angle scattering Small angle X ray scattering Solubility Spodoptera - cytology Trends Vertebrates Viral infections X ray scattering
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