Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory

Links between synaptic plasticity in the lateral amygdala (LA) and Pavlovian fear learning are well established. Neuropeptides including gastrin-releasing peptide (GRP) can modulate LA function. GRP increases inhibition in the LA and mice lacking the GRP receptor (GRPR KO) show more pronounced and p...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e34963-e34963
Hauptverfasser:	Chaperon, Frederique, Fendt, Markus, Kelly, Peter H, Lingenhoehl, Kurt, Mosbacher, Johannes, Olpe, Hans-Rudolf, Schmid, Peter, Sturchler, Christine, McAllister, Kevin H, van der Putten, P Herman, Gee, Christine E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Amygdala - metabolism Amygdala - physiology Animals Anxiety Associative learning Biology Bombesin Bombesin - analogs & derivatives Bombesin - chemistry Bombesin - pharmacology Brain Brain slice preparation Change detection Conditioning Conditioning, Classical - physiology Data processing Extinction behavior Fear Fear & phobias Fear - physiology Fear conditioning Gastrin Gastrin-releasing peptide Gastrin-Releasing Peptide - antagonists & inhibitors Gastrin-Releasing Peptide - genetics Gastrin-Releasing Peptide - metabolism Gene Expression Regulation Learning Long-term potentiation Medicine Memory - physiology Mice Mice, Inbred C57BL Mice, Knockout Neophobia Neurons Neurons - metabolism Neurons - physiology Neuropeptides Neurosciences Peptide Fragments - chemistry Peptides Physiological aspects Physiology Plasticity Psychopharmacology Pyramidal cells Pyramidal Cells - metabolism Pyramidal Cells - physiology Receptors, Bombesin - antagonists & inhibitors Receptors, Bombesin - genetics Receptors, Bombesin - metabolism Rodents Signal Transduction Signaling Social and Behavioral Sciences Synaptic plasticity Taste aversion
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