The co-morbidity burden of children and young adults with autism spectrum disorders
Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults. A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under...
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| Veröffentlicht in: | PloS one 2012-04, Vol.7 (4), p.e33224-e33224 |
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| creator | Kohane, Isaac S McMurry, Andrew Weber, Griffin MacFadden, Douglas Rappaport, Leonard Kunkel, Louis Bickel, Jonathan Wattanasin, Nich Spence, Sarah Murphy, Shawn Churchill, Susanne |
| description | Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults.
A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under age 35 with ASD were characterized by their co-morbidities and conversely, the prevalence of ASD within these comorbidities was measured. The comorbidity prevalence of the younger (Age |
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A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under age 35 with ASD were characterized by their co-morbidities and conversely, the prevalence of ASD within these comorbidities was measured. The comorbidity prevalence of the younger (Age<18 years) and older (Age 18-34 years) individuals with ASD was compared.
19.44% of ASD patients had epilepsy as compared to 2.19% in the overall hospital population (95% confidence interval for difference in percentages 13.58-14.69%), 2.43% of ASD with schizophrenia vs. 0.24% in the hospital population (95% CI 1.89-2.39%), inflammatory bowel disease (IBD) 0.83% vs. 0.54% (95% CI 0.13-0.43%), bowel disorders (without IBD) 11.74% vs. 4.5% (95% CI 5.72-6.68%), CNS/cranial anomalies 12.45% vs. 1.19% (95% CI 9.41-10.38%), diabetes mellitus type I (DM1) 0.79% vs. 0.34% (95% CI 0.3-0.6%), muscular dystrophy 0.47% vs 0.05% (95% CI 0.26-0.49%), sleep disorders 1.12% vs. 0.14% (95% CI 0.79-1.14%). Autoimmune disorders (excluding DM1 and IBD) were not significantly different at 0.67% vs. 0.68% (95% CI -0.14-0.13%). Three of the studied comorbidities increased significantly when comparing ages 0-17 vs 18-34 with p<0.001: Schizophrenia (1.43% vs. 8.76%), diabetes mellitus type I (0.67% vs. 2.08%), IBD (0.68% vs. 1.99%) whereas sleeping disorders, bowel disorders (without IBD) and epilepsy did not change significantly.
The comorbidities of ASD encompass disease states that are significantly overrepresented in ASD with respect to even the patient populations of tertiary health centers. This burden of comorbidities goes well beyond those routinely managed in developmental medicine centers and requires broad multidisciplinary management that payors and providers will have to plan for.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0033224</identifier><identifier>PMID: 22511918</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Adults ; Age ; Autism ; Autoimmune diseases ; Biology ; Boston ; Cardiac patients ; Central nervous system ; Child ; Child Development Disorders, Pervasive - epidemiology ; Child, Preschool ; Children ; Children & youth ; Children's hospitals ; Cohort Studies ; Comorbidity ; Computer Science ; Confidence intervals ; Controlled vocabularies ; Diabetes ; Diabetes mellitus ; Disorders ; Dystrophy ; Electronic Health Records ; Electronic medical records ; Electronic records ; Epilepsy ; Female ; Gastrointestinal diseases ; Health care policy ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Inflammatory bowel diseases ; Informatics ; Information technology ; Intestine ; Male ; Medical records ; Medical research ; Medical schools ; Medicine ; Mental disorders ; Morbidity ; Muscular dystrophy ; Natural language processing ; Patients ; Pediatrics ; Prevalence ; Prevalence studies (Epidemiology) ; Rheumatoid arthritis ; Schizophrenia ; Sex Ratio ; Sleep ; Sleep disorders ; Studies ; Womens health ; Young adults</subject><ispartof>PloS one, 2012-04, Vol.7 (4), p.e33224-e33224</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Kohane et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Kohane et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a5ff3c3e025b669e8298d43a632e4717e86906fce15460ac352afa530a5b13d93</citedby><cites>FETCH-LOGICAL-c692t-a5ff3c3e025b669e8298d43a632e4717e86906fce15460ac352afa530a5b13d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325235/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325235/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22511918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Smalheiser, Neil R.</contributor><creatorcontrib>Kohane, Isaac S</creatorcontrib><creatorcontrib>McMurry, Andrew</creatorcontrib><creatorcontrib>Weber, Griffin</creatorcontrib><creatorcontrib>MacFadden, Douglas</creatorcontrib><creatorcontrib>Rappaport, Leonard</creatorcontrib><creatorcontrib>Kunkel, Louis</creatorcontrib><creatorcontrib>Bickel, Jonathan</creatorcontrib><creatorcontrib>Wattanasin, Nich</creatorcontrib><creatorcontrib>Spence, Sarah</creatorcontrib><creatorcontrib>Murphy, Shawn</creatorcontrib><creatorcontrib>Churchill, Susanne</creatorcontrib><title>The co-morbidity burden of children and young adults with autism spectrum disorders</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults.
A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under age 35 with ASD were characterized by their co-morbidities and conversely, the prevalence of ASD within these comorbidities was measured. The comorbidity prevalence of the younger (Age<18 years) and older (Age 18-34 years) individuals with ASD was compared.
19.44% of ASD patients had epilepsy as compared to 2.19% in the overall hospital population (95% confidence interval for difference in percentages 13.58-14.69%), 2.43% of ASD with schizophrenia vs. 0.24% in the hospital population (95% CI 1.89-2.39%), inflammatory bowel disease (IBD) 0.83% vs. 0.54% (95% CI 0.13-0.43%), bowel disorders (without IBD) 11.74% vs. 4.5% (95% CI 5.72-6.68%), CNS/cranial anomalies 12.45% vs. 1.19% (95% CI 9.41-10.38%), diabetes mellitus type I (DM1) 0.79% vs. 0.34% (95% CI 0.3-0.6%), muscular dystrophy 0.47% vs 0.05% (95% CI 0.26-0.49%), sleep disorders 1.12% vs. 0.14% (95% CI 0.79-1.14%). Autoimmune disorders (excluding DM1 and IBD) were not significantly different at 0.67% vs. 0.68% (95% CI -0.14-0.13%). Three of the studied comorbidities increased significantly when comparing ages 0-17 vs 18-34 with p<0.001: Schizophrenia (1.43% vs. 8.76%), diabetes mellitus type I (0.67% vs. 2.08%), IBD (0.68% vs. 1.99%) whereas sleeping disorders, bowel disorders (without IBD) and epilepsy did not change significantly.
The comorbidities of ASD encompass disease states that are significantly overrepresented in ASD with respect to even the patient populations of tertiary health centers. This burden of comorbidities goes well beyond those routinely managed in developmental medicine centers and requires broad multidisciplinary management that payors and providers will have to plan for.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Autism</subject><subject>Autoimmune diseases</subject><subject>Biology</subject><subject>Boston</subject><subject>Cardiac patients</subject><subject>Central nervous system</subject><subject>Child</subject><subject>Child Development Disorders, Pervasive - epidemiology</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Children's hospitals</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Computer Science</subject><subject>Confidence intervals</subject><subject>Controlled vocabularies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Disorders</subject><subject>Dystrophy</subject><subject>Electronic Health Records</subject><subject>Electronic medical records</subject><subject>Electronic records</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Gastrointestinal diseases</subject><subject>Health care policy</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inflammatory bowel diseases</subject><subject>Informatics</subject><subject>Information technology</subject><subject>Intestine</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Mental disorders</subject><subject>Morbidity</subject><subject>Muscular dystrophy</subject><subject>Natural language processing</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Prevalence</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Rheumatoid arthritis</subject><subject>Schizophrenia</subject><subject>Sex Ratio</subject><subject>Sleep</subject><subject>Sleep disorders</subject><subject>Studies</subject><subject>Womens health</subject><subject>Young 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co-morbidity burden of children and young adults with autism spectrum disorders</title><author>Kohane, Isaac S ; McMurry, Andrew ; Weber, Griffin ; MacFadden, Douglas ; Rappaport, Leonard ; Kunkel, Louis ; Bickel, Jonathan ; Wattanasin, Nich ; Spence, Sarah ; Murphy, Shawn ; Churchill, Susanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a5ff3c3e025b669e8298d43a632e4717e86906fce15460ac352afa530a5b13d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Autism</topic><topic>Autoimmune diseases</topic><topic>Biology</topic><topic>Boston</topic><topic>Cardiac patients</topic><topic>Central nervous system</topic><topic>Child</topic><topic>Child Development Disorders, Pervasive - epidemiology</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & 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Jonathan</au><au>Wattanasin, Nich</au><au>Spence, Sarah</au><au>Murphy, Shawn</au><au>Churchill, Susanne</au><au>Smalheiser, Neil R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The co-morbidity burden of children and young adults with autism spectrum disorders</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-04-12</date><risdate>2012</risdate><volume>7</volume><issue>4</issue><spage>e33224</spage><epage>e33224</epage><pages>e33224-e33224</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults.
A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under age 35 with ASD were characterized by their co-morbidities and conversely, the prevalence of ASD within these comorbidities was measured. The comorbidity prevalence of the younger (Age<18 years) and older (Age 18-34 years) individuals with ASD was compared.
19.44% of ASD patients had epilepsy as compared to 2.19% in the overall hospital population (95% confidence interval for difference in percentages 13.58-14.69%), 2.43% of ASD with schizophrenia vs. 0.24% in the hospital population (95% CI 1.89-2.39%), inflammatory bowel disease (IBD) 0.83% vs. 0.54% (95% CI 0.13-0.43%), bowel disorders (without IBD) 11.74% vs. 4.5% (95% CI 5.72-6.68%), CNS/cranial anomalies 12.45% vs. 1.19% (95% CI 9.41-10.38%), diabetes mellitus type I (DM1) 0.79% vs. 0.34% (95% CI 0.3-0.6%), muscular dystrophy 0.47% vs 0.05% (95% CI 0.26-0.49%), sleep disorders 1.12% vs. 0.14% (95% CI 0.79-1.14%). Autoimmune disorders (excluding DM1 and IBD) were not significantly different at 0.67% vs. 0.68% (95% CI -0.14-0.13%). Three of the studied comorbidities increased significantly when comparing ages 0-17 vs 18-34 with p<0.001: Schizophrenia (1.43% vs. 8.76%), diabetes mellitus type I (0.67% vs. 2.08%), IBD (0.68% vs. 1.99%) whereas sleeping disorders, bowel disorders (without IBD) and epilepsy did not change significantly.
The comorbidities of ASD encompass disease states that are significantly overrepresented in ASD with respect to even the patient populations of tertiary health centers. This burden of comorbidities goes well beyond those routinely managed in developmental medicine centers and requires broad multidisciplinary management that payors and providers will have to plan for.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22511918</pmid><doi>10.1371/journal.pone.0033224</doi><tpages>e33224</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-04, Vol.7 (4), p.e33224-e33224 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1324444214 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Adults Age Autism Autoimmune diseases Biology Boston Cardiac patients Central nervous system Child Child Development Disorders, Pervasive - epidemiology Child, Preschool Children Children & youth Children's hospitals Cohort Studies Comorbidity Computer Science Confidence intervals Controlled vocabularies Diabetes Diabetes mellitus Disorders Dystrophy Electronic Health Records Electronic medical records Electronic records Epilepsy Female Gastrointestinal diseases Health care policy Hospitals Humans Infant Infant, Newborn Inflammatory bowel diseases Informatics Information technology Intestine Male Medical records Medical research Medical schools Medicine Mental disorders Morbidity Muscular dystrophy Natural language processing Patients Pediatrics Prevalence Prevalence studies (Epidemiology) Rheumatoid arthritis Schizophrenia Sex Ratio Sleep Sleep disorders Studies Womens health Young adults |
| title | The co-morbidity burden of children and young adults with autism spectrum disorders |
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