Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways

Proteins involved in mitochondrial metabolic pathways engage in functionally relevant multi-enzyme complexes. We previously described an interaction between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) and glutamate dehydrogenase (GDH) explaining the clinical phenotype of hyperinsulini...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35048-e35048
Hauptverfasser:	Narayan, Srinivas B, Master, Stephen R, Sireci, Anthony N, Bierl, Charlene, Stanley, Paige E, Li, Changhong, Stanley, Charles A, Bennett, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxyacyl CoA Dehydrogenases - chemistry 3-Hydroxyacyl CoA Dehydrogenases - genetics 3-Hydroxyacyl CoA Dehydrogenases - metabolism Aldolase Amino acids Animals Aspartate Aspartate Aminotransferases - chemistry Aspartate Aminotransferases - metabolism Aspartate transaminase Biology Carbamoyl phosphate Carbamoyl-Phosphate Synthase (Ammonia) - chemistry Carbamoyl-Phosphate Synthase (Ammonia) - metabolism Chains Children & youth Chromatography Coenzyme A Dehydrogenase Dehydrogenases Endocrinology Enzymes Experiments Fatty acids Forming Fructose Fructose-bisphosphate aldolase Fructose-Bisphosphate Aldolase - chemistry Fructose-Bisphosphate Aldolase - metabolism Genomics Glutamate Glutamate dehydrogenase Glutamate Dehydrogenase - chemistry Glutamate Dehydrogenase - metabolism Glycolysis Hypoglycemia Insulin Ketogenesis Laboratories Liver Liver - metabolism Medicine Metabolic Networks and Pathways Metabolic pathways Metabolism Mice Mice, Knockout Mitochondria Mitochondria - metabolism Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism Mutation Oxidation Pathology Pathways Pediatrics Phenotypes Plasma Plasmids Proteins Studies Thiols Transaminase
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