Complete mitochondrial genome sequencing reveals novel haplotypes in a Polynesian population

The high risk of metabolic disease traits in Polynesians may be partly explained by elevated prevalence of genetic variants involved in energy metabolism. The genetics of Polynesian populations has been shaped by island hoping migration events which have possibly favoured thrifty genes. The aim of t...

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Veröffentlicht in:	PloS one 2012-04, Vol.7 (4), p.e35026
Hauptverfasser:	Benton, Miles, Macartney-Coxson, Donia, Eccles, David, Griffiths, Lyn, Chambers, Geoff, Lea, Rod
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Archaeology Biology Cladistic analysis Deoxyribonucleic acid DNA DNA sequencing DNA, Mitochondrial - genetics Energy metabolism Environmental science Evolution Gene sequencing Genes Genetic diversity Genetic drift Genetic variance Genetics Genetics, Population Genome, Mitochondrial - genetics Genomes Genomics Haplotypes Haplotypes - genetics Health risks Humans Maoris Medical research Medicine Medicine, Experimental Metabolic disorders Metabolism Migration Mitochondria Mitochondrial DNA Molecular biology Native peoples Nucleotide sequence Nucleotide sequencing Phylogenetics Phylogeny Population Population genetics Populations Positive selection Sequence Analysis, DNA Studies Technology assessment Type 2 diabetes
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