Peptides of the constant region of antibodies display fungicidal activity

Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfu...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e34105-e34105
Hauptverfasser:	Polonelli, Luciano, Ciociola, Tecla, Magliani, Walter, Zanello, Pier Paolo, D'Adda, Tiziana, Galati, Serena, De Bernardis, Flavia, Arancia, Silvia, Gabrielli, Elena, Pericolini, Eva, Vecchiarelli, Anna, Arruda, Denise C, Pinto, Marcia R, Travassos, Luiz R, Pertinhez, Thelma A, Spisni, Alberto, Conti, Stefania
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino acids Analysis Animal models Animals Antibodies Antibodies - chemistry Antibodies - metabolism Antifungal agents Antifungal Agents - chemistry Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antimicrobial agents Biology Biotechnology Candida albicans - drug effects Candidiasis Candidiasis - drug therapy Caspofungin Constant region Cryptococcus neoformans - drug effects Dendritic cells Disease Models, Animal Drug Resistance, Fungal - drug effects Drugs Echinocandins - pharmacology Erythrocytes - drug effects Female Fungal infections Fungi Fungicidal activity Fungicides Health aspects Hemolysis Humans Immune response Immune system Immunoglobulin A Immunoglobulin A - chemistry Immunoglobulin A - metabolism Immunoglobulin Constant Regions Immunoglobulin G Immunoglobulin G - chemistry Immunoglobulin G - metabolism Immunoglobulin M Immunoglobulin M - chemistry Immunoglobulin M - metabolism Infectious diseases Leukemia Lipopeptides Malassezia - drug effects Medicine Mice Mice, Inbred BALB C Microbial Sensitivity Tests Mucosa Mycoses Peptides Peptides - chemistry Peptides - pharmacology Peptides - therapeutic use Proteins Surveillance Synthetic peptides Triazoles Triazoles - pharmacology Yeasts
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