Functional consequences of necdin nucleocytoplasmic localization

Necdin, a MAGE family protein expressed primarily in the nervous system, has been shown to interact with both nuclear and cytoplasmic proteins, but the mechanism of its nucleocytoplasmic transport are unknown. We carried out a large-scale interaction screen using necdin as a bait in the yeast RRS sy...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33786
Hauptverfasser:	Lavi-Itzkovitz, Anat, Tcherpakov, Marianna, Levy, Zehava, Itzkovitz, Shalev, Muscatelli, Francoise, Fainzilber, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Active Transport, Cell Nucleus - physiology Algorithms Amino Acid Motifs Animals Apoptosis Bioinformatics Biology Cell cycle Cell death Cell Nucleus - genetics Cell Nucleus - metabolism Clustering Compartments Cyclic AMP response element-binding protein Cytoplasm - genetics Cytoplasm - metabolism Decomposition Dynactin Dynein Hap1 protein HEK293 Cells Hip Humans Huntingtin Kinases Life Sciences Localization Mice Necdin Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Neurobiology Neurons and Cognition Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclei Nuclei (cytology) Oxidation p53 Protein PC12 Cells Protein binding Protein Binding - physiology Proteins Rats Science Transcription Transcription factors Transport Tumor proteins Yeast
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