Therapeutic effects of autologous tumor-derived nanovesicles on melanoma growth and metastasis

Cancer vaccines with optimal tumor-associated antigens show promise for anti-tumor immunotherapy. Recently, nano-sized vesicles, such as exosomes derived from tumors, were suggested as potential antigen candidates, although the total yield of exosomes is not sufficient for clinical applications. In...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33330
Hauptverfasser:	Lee, Eun-Young, Park, Kyong-Su, Yoon, Yae Jin, Lee, Jaewook, Moon, Hyung-Geun, Jang, Su Chul, Choi, Kyoung-Ho, Kim, Yoon-Keun, Gho, Yong Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Animal models Animals Anticancer properties Antigen (tumor-associated) Antigens Antigens, Neoplasm - administration & dosage Antigens, Neoplasm - therapeutic use Autoantigens Autoantigens - administration & dosage Autoantigens - therapeutic use Autoimmunity Bone marrow Cancer Cancer metastasis Cancer therapies Cancer vaccines Cancer Vaccines - administration & dosage Cancer Vaccines - therapeutic use Dendritic cells Dendritic Cells - immunology Exosomes Exosomes - immunology Exosomes - ultrastructure Female Health aspects Homogenization Immune response Immune system Immunogenicity Immunotherapy Life sciences Lung Neoplasms - prevention & control Lung Neoplasms - secondary Materials Science Medical research Medicine Melanoma Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - secondary Melanoma, Experimental - therapy Metastases Metastasis Mice Mice, Inbred C57BL Microscopy, Electron, Transmission Nanoparticles - administration & dosage Nanoparticles - therapeutic use Nanoparticles - ultrastructure Nuclear engineering Nuclear safety Proteins Rodents Sonication T cell receptors Therapeutic applications Tissues Tumors Vaccination Vaccination - methods Vaccines Vesicles
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