Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C

Many of the neutralising antibodies, isolated to date, display limited activities against the globally most prevalent HIV-1 subtypes A and C. Therefore, those subtypes are considered to be an important target for antibody-based therapy. Variable domains of llama heavy chain antibodies (VHH) have som...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33298
Hauptverfasser:	Strokappe, Nika, Szynol, Agnieszka, Aasa-Chapman, Marlèn, Gorlani, Andrea, Forsman Quigley, Anna, Hulsik, David Lutje, Chen, Lei, Weiss, Robin, de Haard, Hans, Verrips, Theo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Amino Acid Sequence Amino Acid Substitution Amino acids Animals Antibodies Antibodies, Neutralizing - genetics Antigenic determinants Antigens Antiviral agents Binding Binding, Competitive Biology Camelids, New World - genetics Camelids, New World - immunology CD4 antigen CD4 Antigens Comparative analysis Competition Complementarity Determining Regions - genetics Cross Reactions env Gene Products, Human Immunodeficiency Virus - genetics env Gene Products, Human Immunodeficiency Virus - immunology Epitopes Epitopes - genetics Glycoproteins HIV HIV Antibodies - genetics HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV-1 - classification HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus Humans Immunization Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Immunoglobulins In Vitro Techniques Infections Infectious diseases Medicine Microbicides Molecular Sequence Data Mutagenesis, Site-Directed Mutants Neutralization Neutralization Tests Neutralizing Panning Proteins Science Sequence Homology, Amino Acid Vaccines Virology Viruses
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