Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment

Dexamethasone (Dexa) is a widely used glucocorticoid to treat inflammatory diseases; however, a multitude of undesired effects have been reported to arise from this treatment including osteoporosis, obesity, and in children decreased longitudinal bone growth. We and others have previously shown that...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33168
Hauptverfasser:	Zaman, Farasat, Chrysis, Dionisios, Huntjens, Kirsten, Fadeel, Bengt, Sävendahl, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adolescent Animals Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biocompatibility Biology Biomedical materials Bone growth Bones Cancer therapies Cartilage Cell growth Cell Line Children Children & youth Childrens health Chondrocytes Chondrocytes - metabolism Chondrocytes - pathology Chrysis Dexamethasone Dexamethasone - adverse effects Dexamethasone - pharmacology Dual energy X-ray absorptiometry Endocrinology Female Females Gene expression Glucocorticoids Glucocorticoids - adverse effects Glucocorticoids - pharmacology Growth Growth plate Growth Plate - metabolism Growth Plate - pathology Humans Impairment Inflammatory diseases Leukemia Lindgren, Astrid (1907-2002) Male Males Medicin och hälsovetenskap Medicine Mice Mice, Mutant Strains Mitochondria Obesity - chemically induced Obesity - genetics Obesity - metabolism Osteoporosis Osteoporosis - chemically induced Osteoporosis - genetics Osteoporosis - metabolism Pediatrics Peptides Phosphorylation Proteins Ribonucleic acid RNA Rodents siRNA Somatotropin Steroids (Organic compounds) Women
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