Chemical mechanism of UDP-galactopyranose mutase from Trypanosoma cruzi: a potential drug target against Chagas' disease

UDP-galactopyranose mutase (UGM) is a flavoenzyme that catalyzes the conversion of UDP-galactopyranose to UDP-galactofuranose, the precursor of galactofuranose (Galf). Galf is found in several pathogenic organisms, including the parasite Trypanosoma cruzi, the causative agent of Chagas' disease...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e32918-e32918
Hauptverfasser:	Oppenheimer, Michelle, Valenciano, Ana Lisa, Kizjakina, Karina, Qi, Jun, Sobrado, Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anisotropy Biochemistry Biology Catalysis Chagas Disease Chemical kinetics Chemistry Chromatography Drug development Drugs Enzymes Flavin Flavins - metabolism Fluorescence Galactose Galactose - analogs & derivatives Galactose - metabolism Humans Intermediates Intramolecular Transferases - chemistry Intramolecular Transferases - metabolism Kinetics Laboratories Molecular Structure Mutagenesis NADP NADP - metabolism Oxidation-Reduction Oxygen Parasites Protein Conformation Protein expression R&D Reaction kinetics Redox reactions Research & development Substrate Specificity Trypanosoma cruzi Trypanosoma cruzi - enzymology Uridine Diphosphate - analogs & derivatives Uridine Diphosphate - metabolism Vector-borne diseases Virulence Virulence (Microbiology)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!