Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors

Human neonates are highly susceptible to infection, which may be due in part to impaired innate immune function. Neonatal Toll-like receptor (TLR) responses are biased against the generation of pro-inflammatory/Th1-polarizing cytokines, yet the underlying mechanisms are incompletely defined. Here, w...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33419
Hauptverfasser:	Belderbos, Mirjam E, Levy, Ofer, Stalpers, Femke, Kimpen, Jan L, Meyaard, Linde, Bont, Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Blood Blood plasma CD14 antigen Comparative analysis Cord blood Cytokines Deactivation Dendritic cells Depletion Dinoprostone - metabolism Disease susceptibility Experiments Female Fetal Blood - metabolism Health aspects Heat inactivation Helicobacter pylori Humans Immune response Immune system Inactivation Infant, Newborn Infections Inflammation Interleukin 10 Interleukin 12 Interleukin-10 - biosynthesis Interleukin-12 - biosynthesis Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism Lipopolysaccharide Receptors - metabolism Lymphocytes T Male Medicine Mycobacterium tuberculosis MyD88 protein Myeloid Differentiation Factor 88 - metabolism Neonates Newborn babies Newborn infants Ontogeny Pediatrics Plasma Plasma - metabolism Prostaglandin E2 Protein binding Proteins Sepsis T cell receptors Target recognition TLR3 protein TLR4 protein Toll-Like Receptor 3 - metabolism Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - metabolism Toll-Like Receptor 8 - metabolism Toll-like receptors Tuberculosis Vitamin D Vitamin D - metabolism
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