Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster

The Drosophila melanogaster gene CG11501 is up regulated after a septic injury and was proposed to act as a negative regulator of the JAK/STAT signaling pathway. Diedel, the CG11501 gene product, is a small protein of 115 residues with 10 cysteines. We have produced Diedel in Drosophila S2 cells as...

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Veröffentlicht in:	PloS one 2012-03, Vol.7 (3), p.e33416-e33416
Hauptverfasser:	Coste, Franck, Kemp, Cordula, Bobezeau, Vanessa, Hetru, Charles, Kellenberger, Christine, Imler, Jean-Luc, Roussel, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyrthosiphon pisum Animals Antigens Aphids Aphids - chemistry Aphids - genetics Aphids - immunology Binding sites Biochemistry, Molecular Biology Biology Cellular proteins Crystal structure Crystallography Crystallography, X-Ray Cytokines Deoxyribonucleic acid Diffraction DNA DNA viruses Drosophila Drosophila melanogaster Drosophila Proteins Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - immunology Ferredoxin Gene expression Gene sequencing Genes Genetic aspects Genomes Genomics Homology Hydrophobicity Immune response Immune system Immunology Insects Isomerization Janus Kinases Janus Kinases - chemistry Janus Kinases - immunology Kinases Life Sciences Medicine Nucleotide sequence Organisms Phylogenetics Physiological aspects Proline Protein Folding Protein Structure, Tertiary Proteins Residues Signal Transduction Signal Transduction - immunology Signaling STAT Transcription Factors STAT Transcription Factors - chemistry STAT Transcription Factors - genetics STAT Transcription Factors - immunology Structural analysis Transcription Factors Transcription Factors - chemistry Transcription Factors - immunology Viral infections Viruses
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