PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2

Prostaglandin H(1) (PGH(1)) is the cyclo-oxygenase metabolite of dihomo-γ-linolenic acid (DGLA) and the precursor for the 1-series of prostaglandins which are often viewed as "anti-inflammatory". Herein we present evidence that PGH(1) is a potent activator of the pro-inflammatory PGD(2) re...

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Veröffentlicht in:	PloS one 2012, Vol.7 (3), p.e33329-e33329
Hauptverfasser:	Schröder, Ralf, Xue, Luzheng, Konya, Viktoria, Martini, Lene, Kampitsch, Nora, Whistler, Jennifer L, Ulven, Trond, Heinemann, Akos, Pettipher, Roy, Kostenis, Evi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Asthma Atopic dermatitis Biological activity Biology Biosensors Calcium Calcium Signaling - genetics Coronary vessels Cytokines Dermatitis Endothelial cells Endothelial Cells - metabolism Eosinophils Fatty acids Female HEK293 Cells Hemopoiesis Humans Hypersensitivity - drug therapy Hypersensitivity - genetics Hypersensitivity - metabolism Inflammation Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - metabolism Leukocyte migration Leukocytes (eosinophilic) Linolenic acid Lipocalins - genetics Lipocalins - metabolism Lymphocytes Lymphocytes T Male Metabolites Microvasculature Oxygenase Pharmacology Physiological effects Physiology Precursors Prostaglandin D2 synthase Prostaglandin endoperoxide synthase Prostaglandins Prostaglandins H - genetics Prostaglandins H - metabolism Pulmonary arteries Receptors, Immunologic - agonists Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Prostaglandin - agonists Receptors, Prostaglandin - genetics Receptors, Prostaglandin - metabolism Smooth muscle Th2 Cells - metabolism Ulcers Young adults
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